Regulation of Drug Transport Proteins and Drug Metabolizing Enzymes by Nuclear Receptors

核受体对药物转运蛋白和药物代谢酶的调节

• 批准号: RGPIN-2016-05056
• 负责人: Urquhart, Bradley
• 金额: $ 2.26万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629212
• 关键词: Regulation; Drug; Transport; Proteins; Metabolizing

- The intracellular concentration of chemical molecules determines their activity and toxicity. This applies not only to drugs but also to endogenous molecules such as vitamins and hormones. Membrane transport proteins act as a gateway to determine the concentration available to act on intracellular targets. Intracellular enzymes mediate the metabolism of numerous molecules to detoxify them and/or render them more suitable for elimination. Proteins called nuclear receptors tightly regulate the amount of these transporters and metabolic enzymes. The overall goal of this research program is to further our understanding of the processes that determine the activity of drug transporters and metabolic enzymes. This will help us understand the way the body handles drugs, vitamins and other hormones.

- 化学分子的细胞内浓度决定了它们的活性和毒性。这不仅适用于药物，也适用于内源性分子，如维生素和激素。膜转运蛋白作为一个网关，以确定浓度可用于作用于细胞内的目标。细胞内酶介导许多分子的代谢以使它们解毒和/或使它们更适合于消除。被称为核受体的蛋白质严格调节这些转运蛋白和代谢酶的数量。这项研究计划的总体目标是进一步了解决定药物转运蛋白和代谢酶活性的过程。这将帮助我们了解身体处理药物、维生素和其他激素的方式。