Investigating the role of Reep5 in formation, maintenance, and function of the endoplasmic reticulum

研究 Reep5 在内质网形成、维持和功能中的作用

• 批准号: RGPIN-2016-05618
• 负责人: Gramolini, Anthony
• 金额: $ 2.77万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629277
• 关键词: Investigating; role; Reep5; formation; maintenance

The Endoplasmic Reticulum (ER) is a dynamic multi-functional organelle found in eukaryotes. It is a specialized organ responsible for many functions, including Ca2+ cycling, protein translation and trafficking. An important group of proteins that mediate formation and maintenance of the ER are proteins with ‘reticulon homology domains (RHD). One group of RHD proteins are the receptor expression-enhancing proteins (REEPs). The precise role of REEPs in ER formation, maintenance, and responses to ER stress is not well understood. Our ongoing proteomic studies have identified REEP5 to be an evolutionary-conserved, cardiac cell-enriched, membrane protein that is the dominant REEP in the heart.

内质网是真核生物中发现的一种动态的多功能细胞器。它是一个专门的器官，负责许多功能，包括钙循环、蛋白质翻译和运输。调节内质网形成和维持的一组重要蛋白质是具有网状同源结构域(RHD)的蛋白质。其中一组RHD蛋白是受体表达增强蛋白(REEP)。Reep在内质网形成、维持和对内质网应激反应中的确切作用尚不清楚。我们正在进行的蛋白质组学研究发现，REEP5是一种进化保守的、富含心肌细胞的膜蛋白，是心脏中占主导地位的REEP。