Molecular Determinants of Vertebrate Vasculature and Development

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Vertebrate vascular system is vital for blood circulation, gas & metabolite exchange, fluid balance & immune cell trafficking. Vessel formation in embryos is called vasculogenesis, and in postnatal life, angiogenesis. Angiogenesis participates in tissue regeneration, inflammation and tumor pathogenesis. The process of vasculogenesis and the molecular determinants involved in vasculogenesis is not clear yet. Micro(mi)RNAs are short noncoding RNAs, which negatively regulate expression of target genes to play key roles in embryogenesis, tissue homeostasis, and pathogenesis. Prostaglandin(PG) E2 promotes inflammation, can regulate stem cells and induce inflammation associated miRNAs by upregulating EP4, a receptor for PGE2. PGE2 mediated functions can be inhibited by blocking EP4 activity. The biology of PGE2 and miRNAs in vertebrate development and angiogenesis are not known.