Epigenetic Regulation of Adult Hippocampal Neurogenesis

成人海马神经发生的表观遗传调控

• 批准号: RGPIN-2016-05656
• 负责人: Wang, Jing
• 金额: $ 2.26万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629356
• 关键词: Epigenetic; Regulation; Adult; Hippocampal; Neurogenesis

Knowing the adult human brain has the innate ability to produce new neurons throughout life has propelled the study of adult neurogenesis to the forefront of scientific research. While numerous factors, such as aging and exercise, have been identified to regulate adult hippocampal neurogenesis, there is currently a gap in our knowledge with respect to the molecular mechanisms that cell-autonomously modulate hippocampal neural precursor development to contribute to hippocampal neurogenesis. Since epigenetics has emerged as a molecular interface that integrates extrinsic signals to determine intrinsic gene expressions, our long term goal is to understand how epigenetic mechanisms cell-autonomously regulate adult hippocampal neurogenesis. On the basis of our recent fruitful research regarding the role of a histone acetyltransferase, CBP (CREB binding protein) in regulating neural stem cell biology, we

知道成年人的大脑具有在一生中产生新神经元的先天能力，这将成人神经发生的研究推向了科学研究的前沿。虽然许多因素，如老化和运动，已被确定为调节成人海马神经发生，目前有一个缺口，我们的知识与分子机制，细胞自主调节海马神经前体发育，以促进海马神经发生。由于表观遗传学已经成为一个分子界面，整合外部信号，以确定内在的基因表达，我们的长期目标是了解表观遗传机制细胞自主调节成年海马神经发生。基于我们最近关于组蛋白乙酰转移酶CBP（CREB结合蛋白）在调节神经干细胞生物学中的作用的富有成效的研究，我们