Epigenetic Regulation of Adult Hippocampal Neurogenesis

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Knowing the adult human brain has the innate ability to produce new neurons throughout life has propelled the study of adult neurogenesis to the forefront of scientific research. While numerous factors, such as aging and exercise, have been identified to regulate adult hippocampal neurogenesis, there is currently a gap in our knowledge with respect to the molecular mechanisms that cell-autonomously modulate hippocampal neural precursor development to contribute to hippocampal neurogenesis. Since epigenetics has emerged as a molecular interface that integrates extrinsic signals to determine intrinsic gene expressions, our long term goal is to understand how epigenetic mechanisms cell-autonomously regulate adult hippocampal neurogenesis. On the basis of our recent fruitful research regarding the role of a histone acetyltransferase, CBP (CREB binding protein) in regulating neural stem cell biology, we