Epigenetic regulation of key developmental genes from embryo to adult

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We performed the epigenomic analysis of pluripotent blastula embryos and adult myotome and liver in medaka fish. We revealed that, in developmental gene loci, the size of hypomethylated DNA domain (HMD) positively correlates with the repression levels of developmental gene expression in blastula, and HMDs become shortened when the adjacent gene is actively expressed in adult tissues. The comparative analyses with human ES cells, zebrafish embryos and adult muscle showed the conservation of the correlation between HMD size and the repression levels of developmental genes. Therefore, this study highlights the novel features of developmental gene regulation mediated by the size of epigenetic domain from pluripotent embryos to adult.