Mechanisms of neural specification and patterning during planarian brain regeneration

涡虫脑再生过程中神经规范和模式的机制

• 批准号: RGPIN-2016-06354
• 负责人: Pearson, Bret
• 金额: $ 4.66万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629358
• 关键词: Mechanisms; neural; specification; patterning; during

Decades of elegant work have described neural development in the embryos of many model organisms, which has shown that neural development is the precise coordination of neural stem cells in space and time in order to make a functioning nervous system with appropriate cell-type ratios. However, it is not known how these developmental principles apply to adult organisms as neurons are turned over (homeostasis) or are replaced following injury (regeneration). In our first NSERC funding term, we started to investigate adult neural homeostasis and regeneration using the freshwater planarian (flatworm;

几十年来，人们已经描述了许多模式生物胚胎中的神经发育，这表明神经发育是神经干细胞在空间和时间上的精确协调，以使神经系统具有适当的细胞类型比例。然而，目前尚不清楚这些发育原则如何适用于成年生物体，因为神经元被翻转（稳态）或在损伤后被替换（再生）。在我们的第一个NSERC资助期间，我们开始研究成人神经稳态和再生使用淡水涡虫（扁形虫;