Regulation of cell migration by biochemical and mechanical environmental cues

生化和机械环境因素对细胞迁移的调节

• 批准号: RGPIN-2015-05114
• 负责人: Plotnikov, Sergey
• 金额: $ 2.33万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629380
• 关键词: Regulation; cell; migration; biochemical; mechanical

Cell migration is a fundamental phenomenon that is critical for life of unicellular and multicellular organisms. Simple organisms, such as amebae, have to migrate to find food and to mate. Complexity of multicellular organisms, such as vertebrates, brings the necessity for individual cells and groups of cells to position themselves during developmental morphogenesis that is largely achieved through directed cell migration. In the adult, directed migration plays an important role in a wide range of physiological and pathological processes, including renewal of skin and intestinal epithelium, immune system function, and wound healing, as well as cancer metastasis and cardiovascular diseases.

细胞迁移是单细胞和多细胞生物生命的一种基本现象。简单的生物，如变形虫，必须迁徙寻找食物和交配。复杂的多细胞生物，如脊椎动物，需要单个细胞和细胞群在发育形态发生过程中定位自己，这主要是通过定向细胞迁移来实现的。在成人中，定向迁移在广泛的生理和病理过程中起着重要作用，包括皮肤和肠上皮的更新，免疫系统功能，伤口愈合，以及癌症转移和心血管疾病。