Molecular mechanisms of elastic fiber formation

弹性纤维形成的分子机制

• 批准号: RGPIN-2016-06278
• 负责人: Reinhardt, Dieter
• 金额: $ 3.93万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629383
• 关键词: Molecular; mechanisms; elastic; fiber; formation

Elastic fibers provide elasticity to tissues that undergo repeated stretch, such as large arteries, lung, skin and elastic ligaments. The long term Discovery program goal is to understand the fundamental mechanisms of elastic fiber formation and use this information to advance the generation of new materials that require elasticity. The overarching objectives of the program is to decipher the properties of essential components and their functional relationships with each other and with cells, and to analyze how these mechanisms are used to form fully functional elastic fibers.

弹性纤维为反复拉伸的组织提供弹性，如大动脉、肺、皮肤和弹性韧带。“发现”项目的长期目标是了解弹性纤维形成的基本机制，并利用这些信息推进需要弹性的新材料的产生。该计划的总体目标是破译基本成分的特性及其相互之间和与细胞的功能关系，并分析这些机制如何用于形成功能齐全的弹性纤维。