The roles of the CaVbeta2 subunit and the synaptic protein interaction site in determining Ca2+ channel function in neuroendocrine secretion

CaVbeta2亚基和突触蛋白相互作用位点在神经内分泌分泌中Ca2通道功能中的作用

• 批准号: RGPIN-2015-05536
• 负责人: Fisher, Thomas
• 金额: $ 2.19万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629398
• 关键词: roles; CaVbeta2; subunit; synaptic; protein

The flow of Ca2+ into neurons through voltage-gated Ca2+ (CaV) channels triggers the release of neurotransmitters and hormones and the intracellular targeting of these channels is therefore of fundamental importance for intercellular communication. CaV channels are composed of a CaValpha1 subunit and one of four CaVbeta subunits, which may help transport channels to axon terminals. The two types of Ca2+ channels most important in synaptic release (CaV2.1 and CaV2.2) contain a peptide sequence that allows them to interact with synaptic proteins and is thus called the “synprint” site.

Ca2+通过电压门控Ca2+ (CaV)通道进入神经元触发神经递质和激素的释放，因此这些通道的细胞内靶向对细胞间通讯至关重要。CaV通道由一个CaValpha1亚基和四个CaVbeta亚基中的一个组成，这可能有助于将通道运输到轴突末端。在突触释放中最重要的两种Ca2+通道（CaV2.1和CaV2.2）包含一个肽序列，使它们能够与突触蛋白相互作用，因此被称为“synprint”位点。