Protein Tyrosine Phosphatase Alpha in Integrin Signaling and Cell Movement

细胞运动是一个基本的生理过程。细胞运动的主要决定因素是整合素，细胞膜上的受体，其协调粘附性细胞-基质接触与肌动蛋白细胞骨架的连续重组。整合素结合启动细胞内信号传导，其驱动称为粘着斑（FA）的多蛋白复合物的组装。FA信号既控制细胞骨架重塑，也控制它们自身的动态组装和拆卸，以调节细胞的形状和运动。

Cell movement is a fundamental physiological process. Principal determinants of cell motility are the integrins, receptors on the cell membrane that co-ordinate adhesive cell-substrate contacts with continual re-organization of the actin cytoskeleton. Integrin engagement initiates intracellular signaling that drives the assembly of multiprotein complexes known as focal adhesions (FAs). FA signaling controls both cytoskeletal remodeling and also their own dynamic assembly and disassembly to regulate cell shape and movement.