Tyrosine Kinase Signaling in Nuclear Morphodynamics

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Eukaryotic cells, including human cells, are divided into compartments called organelles that have evolved to perform specialized functions while protecting the rest of the cell from potentially harmful activities. This partition into organelles presents cells with big challenges in terms of coordination of cellular activities. In response to changes in the environment or to internal alterations, cells must rearrange the structure and positioning of their organelles in a manner that is coordinated with changes of their overall shape. The nucleus, the biggest organelle of a cell, is well known for its crucial function in protecting and controlling the genetic information. Like any other organelles, however, the nucleus is highly dynamic and undergoes remarkable changes in its shape and position within a cell. Such changes are believed to have profound impacts on the proper functioning of cells within tissues, hence on tissue integrity. These so-called