Tyrosine Kinase Signaling in Nuclear Morphodynamics

核形态动力学中的酪氨酸激酶信号转导

• 批准号: RGPIN-2016-05849
• 负责人: Lavoie, Josée
• 金额: $ 2.26万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629449
• 关键词: Tyrosine; Kinase; Signaling; Nuclear; Morphodynamics

Eukaryotic cells, including human cells, are divided into compartments called organelles that have evolved to perform specialized functions while protecting the rest of the cell from potentially harmful activities. This partition into organelles presents cells with big challenges in terms of coordination of cellular activities. In response to changes in the environment or to internal alterations, cells must rearrange the structure and positioning of their organelles in a manner that is coordinated with changes of their overall shape. The nucleus, the biggest organelle of a cell, is well known for its crucial function in protecting and controlling the genetic information. Like any other organelles, however, the nucleus is highly dynamic and undergoes remarkable changes in its shape and position within a cell. Such changes are believed to have profound impacts on the proper functioning of cells within tissues, hence on tissue integrity. These so-called

真核细胞，包括人类细胞，被分成称为细胞器的隔室，这些隔室已经进化到执行专门的功能，同时保护细胞的其余部分免受潜在的有害活动的影响。细胞器的这种划分在细胞活动的协调方面给细胞带来了巨大的挑战。为了应对环境的变化或内部的变化，细胞必须重新排列其细胞器的结构和位置，以与其整体形状的变化相协调。细胞核是细胞中最大的细胞器，在保护和控制遗传信息方面起着至关重要的作用。然而，像任何其他细胞器一样，细胞核是高度动态的，在细胞内的形状和位置都会发生显着变化。这种变化被认为对组织内细胞的正常功能具有深远的影响，因此对组织完整性具有深远的影响。这些所谓的