Exploring the mitochondrial phosphoproteome during metabolic stress

点击翻译按钮获取中文摘要

Mitochondria convert most of the energy contained in nutrients into ATP, which is required to perform all cellular biochemical processes needing energy. Therefore, the mitochondrial metabolism needs to be tightly regulated to maintain survival of cells during metabolic stress. For instance, the mitochondrial ATP production needs to be maintained during low nutrient availability whereas it must be increased during exercise to match the energetic needs of cells. Kinases emerged recently as important regulators of mitochondrial functions. These enzymes change the properties of proteins by adding a phosphate group. Although we know that several kinases can be localized in mitochondria where they can target different proteins, little is known about their importance in the regulation of the mitochondrial metabolism during challenging metabolic conditions. Interestingly, the activity of kinases can be activated by several sub-products of the metabolism which are affected in such conditions. Since mitochondria are key regulators of these metabolites, kinases localized within mitochondria could represent direct messengers to regulate the mitochondrial metabolism during metabolic stress.