Collaborative Research: Unraveling the phylogenetic and evolutionary patterns of fragmented mitochondrial genomes in parasitic lice

合作研究:揭示寄生虱线粒体基因组片段的系统发育和进化模式

基本信息

  • 批准号:
    2328119
  • 负责人:
  • 金额:
    $ 25.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2024
  • 资助国家:
    美国
  • 起止时间:
    2024-02-01 至 2027-01-31
  • 项目状态:
    未结题

项目摘要

Mitochondria are critical for the survival of organisms because they provide the energy necessary for cells to function. Because of their importance, even small changes to the mitochondria can have drastic consequences for the cell. This includes changes to the molecules (chromosomes) that contain genetic information in the mitochondria. Genetic information in the mitochondria is usually contained on a single, circular chromosome. However, chromosomes in the mitochondria of some species of lice (small, parasitic insects of mammals and birds) are separated onto several smaller, circular fragments. Fragmented chromosomes arose multiple times throughout the evolutionary history of lice, but are very rare and harmful in most other animals. Very little is known about how or why these fragmented chromosomes exist in lice. In this project, the researchers will seek to understand fragmented mitochondrial chromosomes by comparing genetic information from many different species of lice. The results from this research will provide insight into how cells work and could help scientists to better understand human mitochondrial diseases. The project will support multiple outreach opportunities in Arkansas, Indiana, and Illinois through the creation of displays and presentations at community STEM events. The project will also provide training for a postdoctoral researcher, graduate students, and undergraduate students working on the project, and for the broader research community through two workshops on analyzing mitochondrial genome data. The research will focus on three hypotheses related to fragmented mitochondrial genomes (mitogenomes) in lice: 1) non-functional, nuclear-encoded mitochondrial genes can result in fragmentation of the mitogenome, 2) fragmented mitogenomes allow for a reduction in purifying selection from mito-nuclear incompatibility, and 3) selection for a balanced number of mitochondrial gene copies can promote an increase in fragmentation. To test these hypotheses, the researchers will use whole genome sequence data to assemble mitogenomes and relevant nuclear genes from 444 species of lice that represent four distinct clades that have varying levels of mitogenome fragmentation. With these data, the researchers will then reconstruct the evolutionary history of mitogenome structure and compare genomic content in the four clades of lice. Specifically, the researchers will 1) estimate a phylogenomic trees to reconstruct the evolutionary patterns of mitochondrial fragmentation, 2) examine the absence of nuclear-encoded mitochondrial genes, 3) test for signatures of relaxed or positive selection, and 4) quantify the relative copy number of mitochondrial genes. This project is jointly funded by Systematics and Biodiversity Science and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
线粒体对生物体的生存至关重要,因为它们提供细胞发挥功能所需的能量。由于它们的重要性,即使是线粒体的微小变化也会对细胞产生严重影响。这包括线粒体中包含遗传信息的分子(染色体)的变化。线粒体中的遗传信息通常包含在单个环状染色体上。然而,某些种类的虱子(哺乳动物和鸟类的小型寄生昆虫)的线粒体中的染色体被分离成几个较小的圆形片段。在虱子的进化史中,染色体碎片多次出现,但在大多数其他动物中非常罕见和有害。关于这些碎片化的染色体如何或为什么存在于虱子中,我们知之甚少。在这个项目中,研究人员将通过比较许多不同种类的虱子的遗传信息来了解片段化的线粒体染色体。这项研究的结果将为细胞如何工作提供深入了解,并可以帮助科学家更好地了解人类线粒体疾病。该项目将通过在社区STEM活动中创建展示和演示来支持阿肯色州、印第安纳州和伊利诺伊州的多个外展机会。该项目还将为从事该项目的博士后研究人员、研究生和本科生提供培训,并通过两个关于分析线粒体基因组数据的研讨会为更广泛的研究界提供培训。这项研究将集中在三个假设相关的片段化线粒体基因组(有丝分裂基因组)在虱子:1)非功能性,核编码的线粒体基因可以导致分裂的有丝分裂基因组,2)片段化的有丝分裂基因组允许减少纯化选择从线粒体核不相容性,和3)选择平衡数量的线粒体基因拷贝可以促进碎片的增加。为了验证这些假设,研究人员将使用全基因组序列数据来组装来自444种虱子的有丝分裂基因组和相关核基因,这些虱子代表了具有不同水平的有丝分裂基因组片段的四个不同分支。有了这些数据,研究人员将重建有丝分裂基因组结构的进化历史,并比较虱子四个分支的基因组内容。具体来说,研究人员将1)估计一个新的基因组树来重建线粒体片段化的进化模式,2)检查核编码线粒体基因的缺失,3)测试放松或积极选择的签名,以及4)量化线粒体基因的相对拷贝数。该项目由系统学和生物多样性科学以及刺激竞争性研究的既定计划(EPSCoR)共同资助。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Stephen Cameron其他文献

Critical local well‐posedness for the fully nonlinear Peskin problem
全非线性 Peskin 问题的临界局部适定性
The Nevanlinna-Pick problem on the closed unit disk: Minimal norm rational solutions of low degree
闭单位圆盘上的 Nevanlinna-Pick 问题:低次最小范数有理解
Eventual regularization for the 3D Muskat problem: Lipschitz for finite time implies global existence
3D Muskat 问题的最终正则化:有限时间的 Lipschitz 意味着全局存在
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Stephen Cameron
  • 通讯作者:
    Stephen Cameron
Eventual Regularization of Fractional Mean Curvature Flow
分数平均曲率流的最终正则化
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Stephen Cameron
  • 通讯作者:
    Stephen Cameron
Velocity decay estimates for Boltzmann equation with hard potentials
具有硬势的玻尔兹曼方程的速度衰减估计
  • DOI:
    10.1088/1361-6544/ab7729
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    1.7
  • 作者:
    Stephen Cameron;Stanley Snelson
  • 通讯作者:
    Stanley Snelson

Stephen Cameron的其他文献

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{{ truncateString('Stephen Cameron', 18)}}的其他基金

Collaborative Research: Digitization TCN: Digitizing collections to trace parasite-host associations and predict the spread of vector-borne disease
合作研究:数字化 TCN:数字化馆藏以追踪寄生虫-宿主关联并预测媒介传播疾病的传播
  • 批准号:
    1901932
  • 财政年份:
    2019
  • 资助金额:
    $ 25.15万
  • 项目类别:
    Continuing Grant
PostDoctoral Research Fellowship
博士后研究奖学金
  • 批准号:
    1902750
  • 财政年份:
    2019
  • 资助金额:
    $ 25.15万
  • 项目类别:
    Fellowship Award
Schools Robot Olympics
学校机器人奥运会
  • 批准号:
    EP/I017585/1
  • 财政年份:
    2011
  • 资助金额:
    $ 25.15万
  • 项目类别:
    Research Grant
Testing the Utility of Mitochondrial Genome Rearrangements as Phylogenetic Markers in Ischnocera (Insecta:Phthiraptera)
测试线粒体基因组重排作为 Ischnocera(昆虫纲:Phthiraptera)系统发育标记的效用
  • 批准号:
    0444972
  • 财政年份:
    2005
  • 资助金额:
    $ 25.15万
  • 项目类别:
    Standard Grant
Life-Cycle Choices and the Evolution of Youth Labor Markets
生命周期选择和青年劳动力市场的演变
  • 批准号:
    9730657
  • 财政年份:
    1998
  • 资助金额:
    $ 25.15万
  • 项目类别:
    Continuing Grant

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合作研究:揭示寄生虱线粒体基因组片段的系统发育和进化模式
  • 批准号:
    2328117
  • 财政年份:
    2024
  • 资助金额:
    $ 25.15万
  • 项目类别:
    Standard Grant
Collaborative Research: Unraveling the phylogenetic and evolutionary patterns of fragmented mitochondrial genomes in parasitic lice
合作研究:揭示寄生虱线粒体基因组片段的系统发育和进化模式
  • 批准号:
    2328118
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