Molecular pathways connecting NMDA receptors to synapse number

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NMDA receptors (NMDARs) are a type of glutamate neurotransmitter receptor that is widely expressed in the central nervous system. NMDARs are highly conserved among mammals and are found throughout the animal kingdom. One reason for their presence in all animals is that they play a fundamental role in the process of synaptic plasticity. Synaptic plasticity refers to the process by which neurons change the strength and number of connections in the developing brain and throughout life.