Molecular pathways connecting NMDA receptors to synapse number

连接 NMDA 受体与突触数量的分子途径

• 批准号: RGPIN-2017-06438
• 负责人: Ramsey, Amy
• 金额: $ 1.89万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629579
• 关键词: Molecular; pathways; connecting; NMDA; receptors

NMDA receptors (NMDARs) are a type of glutamate neurotransmitter receptor that is widely expressed in the central nervous system. NMDARs are highly conserved among mammals and are found throughout the animal kingdom. One reason for their presence in all animals is that they play a fundamental role in the process of synaptic plasticity. Synaptic plasticity refers to the process by which neurons change the strength and number of connections in the developing brain and throughout life.

NMDA受体（NMDARs）是一种广泛表达于中枢神经系统的谷氨酸神经递质受体。NMDARs在哺乳动物中高度保守，在动物王国中随处可见。它们在所有动物中存在的一个原因是它们在突触可塑性过程中起着重要作用。突触可塑性指的是神经元在发育中的大脑和整个生命过程中改变连接的强度和数量的过程。