Role of Hippo signaling in myofibroblasts during gut regeneration and tumorigenesis.

Hippo 信号在肠道再生和肿瘤发生过程中肌成纤维细胞中的作用。

• 批准号: 370985
• 负责人: Gregorieff Alex
• 金额: $ 47.37万
• 依托单位: Research Institute of the McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=370985&lang=en
• 关键词: Colorectal Cancer; Cre/Lox Technology; Hippo Signalling; Intestinal Myofibroblasts; Intestinal Regeneration; Intestinal Stem Cells; Organoids; Stromal/Epithelial Signalling

Cancer arises as consequence of mutations that occur in genes, which control the ability of cells to divide. Typically these mutations render normal cells capable of multiplying indefinitely, as well as spreading throughout the human body. The proficiency

癌症是由于控制细胞分裂能力的基因发生突变而产生的。通常，这些突变使正常细胞能够无限繁殖，并在整个人体内扩散。熟练度