Protein-Protein Interactions Involved in Siderophore Biosynthesis and Secretion

参与铁载体生物合成和分泌的蛋白质-蛋白质相互作用

• 批准号: RGPIN-2017-04796
• 负责人: Pawelek, Peter
• 金额: $ 1.89万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629677
• 关键词: Protein; Interactions; Involved; Siderophore; Biosynthesis

Most metabolic processes that support life require protein-protein interactions. Furthermore, metabolic enzymes that participate in such processes are often clustered into large complexes known as metabolons. Organization of enzymes into metabolons can enhance the efficiency of metabolic processes and can facilitate membrane localization. My laboratory studies the role of protein-protein interactions in siderophore-mediated bacterial iron uptake. Siderophores are small-molecule iron chelators that bacteria synthesize and secrete to obtain scarce iron from extracellular environment. Little is currently known about how the enzymes involved in siderophore biosynthesis are organized within a bacterial cell. We now have evidence that the enzymes involved in the biosynthesis of the

大多数维持生命的新陈代谢过程都需要蛋白质之间的相互作用。此外，参与这一过程的代谢酶通常聚集成称为代谢素的大型复合体。将酶组织成代谢物可以提高代谢过程的效率，并有助于膜的定位。我的实验室研究蛋白质-蛋白质相互作用在铁载体介导的细菌铁摄取中的作用。铁载体是细菌合成和分泌的小分子铁络合剂，从细胞外环境中获得稀缺的铁。目前人们对参与铁载体生物合成的酶在细菌细胞内是如何组织的知之甚少。我们现在有证据表明，参与生物合成的酶