Mechanistic studies of a new family of bacterial RNA chaperones

细菌RNA伴侣新家族的机制研究

• 批准号: RGPIN-2016-05163
• 负责人: Glover, JNMark
• 金额: $ 3.93万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629689
• 关键词: Mechanistic; studies; new; family; bacterial

Small non-coding RNAs (sRNAs) regulate gene expression in essentially all bacterial species. My laboratory showed that the regulation of gene expression in the F family of bacterial plasmids is controlled by an RNA chaperone, called FinO, that facilitates the interactions of antisense RNAs with their mRNA targets. In a new collaboration with Xavier Charpentier (Lyons), we have now shown that FinO-like chaperones exist in a variety of bacterial species where they control diverse regulatory processes. Charpentier has recently used genomic approaches to identify an sRNA-mRNA pair that regulates DNA transduction in

小的非编码rna （sRNAs）基本上在所有细菌物种中调控基因表达。我的实验室表明，细菌质粒F家族的基因表达调控是由一种叫做FinO的RNA伴侣控制的，它促进了反义RNA与它们的mRNA靶标的相互作用。在与Xavier Charpentier （Lyons）的一项新合作中，我们现在已经证明，fino样伴侣存在于各种细菌物种中，它们控制着各种调节过程。Charpentier最近使用基因组方法鉴定了调节DNA转导的sRNA-mRNA对