Mechanisms of membrane biogenesis and peptidoglycan remodeling during sporulation

孢子形成过程中膜生物发生和肽聚糖重塑的机制

• 批准号: RGPIN-2015-04345
• 负责人: Tocheva, Elitza
• 金额: $ 3.14万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629711
• 关键词: Mechanisms; membrane; biogenesis; peptidoglycan; remodeling

My research program seeks to understand the structural and functional changes that occur in the bacterial cell envelope during growth and cell division. Although bacteria occupy every niche in the biosphere and sustain life on this planet, they are faced with unpredictable environments. To survive, they have evolved a sophisticated, multilayered cell envelope structure composed of either one or two membranes and a mesh-like polymer (peptidoglycan) that protects them while allowing the selective passage of nutrients and waste products. Spatial and temporal regulation of changes in the cell envelope is essential to bacterial growth and division. Moreover, the bacterial cell envelope is a major target for antimicrobials. Thus, research into the bacterial cell envelope provides insight into fundamental biological processes and is critical for understanding human health and disease.

我的研究计划旨在了解在生长和细胞分裂过程中细菌细胞包膜中发生的结构和功能变化。虽然细菌占据了生物圈中的每一个生态位，并在这个星球上维持生命，但它们面临着不可预测的环境。为了生存，它们进化出一种复杂的多层细胞包膜结构，由一层或两层膜和一种网状聚合物（肽聚糖）组成，这种聚合物保护它们，同时允许营养物质和废物选择性通过。细胞被膜变化的时空调控对细菌的生长和分裂至关重要。此外，细菌细胞包膜是抗微生物剂的主要靶标。因此，对细菌细胞包膜的研究提供了对基本生物过程的深入了解，对于了解人类健康和疾病至关重要。