Exploring the Role of Bacterial Translation Factors in Metabolism and Stress Resistance

探索细菌翻译因子在代谢和应激抵抗中的作用

• 批准号: RGPIN-2015-05292
• 负责人: Navarre, William
• 金额: $ 3.79万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629715
• 关键词: Exploring; Role; Bacterial; Translation; Factors

Bacteria are living cells that routinely encounter stressful situations and must adapt to survive. Stresses can include acids, detergents, antibiotics, heat, too much salt, toxic metals, and the immune systems of animals that they infect. Bacterial cells can do many things to protect themselves from such stresses including detoxifying or eliminating the cause of stress or by changing some aspect of their physiology (not unlike how a human sweats when they are hot). Not all environments are equal and the way a bacterial cell survives in one environment may be detrimental in another. Bacteria have therefore evolved to link particular stress responses to cues they detect in their local environment. The details of what signals are being sensed and exactly how this information is integrated into an effective response is the focus of this research.

细菌是常规遇到压力情况并必须适应生存的活细胞。应力可以包括酸，洗涤剂，抗生素，热量，过多的盐，有毒金属以及它们感染的动物的免疫系统。细菌细胞可以做许多事情来保护自己免受这种压力，包括排毒或消除压力原因或通过改变其生理学的某些方面（与人类热时汗水的汗水不同）。并非所有环境都是相等的，并且细菌细胞在一个环境中生存的方式可能在另一种环境中有害。因此，细菌已经演变为将特定的压力反应与他们在本地环境中检测到的线索联系起来。这项研究的重点是感知哪些信号的详细信息以及如何将此信息集成到有效的响应中。