Exploring the Role of Bacterial Translation Factors in Metabolism and Stress Resistance

细菌是活细胞，经常遇到压力的情况下，必须适应生存。压力可以包括酸，洗涤剂，抗生素，热，太多的盐，有毒金属，以及它们感染的动物的免疫系统。细菌细胞可以做很多事情来保护自己免受这种压力的影响，包括解毒或消除压力的原因，或者改变它们生理学的某些方面（这与人类在炎热时出汗的方式不同）。并非所有的环境都是平等的，细菌细胞在一种环境中生存的方式可能在另一种环境中是有害的。因此，细菌已经进化到将特定的压力反应与它们在当地环境中检测到的线索联系起来。什么样的信号被感知的细节，以及这些信息是如何被整合到一个有效的反应是这项研究的重点。

Bacteria are living cells that routinely encounter stressful situations and must adapt to survive. Stresses can include acids, detergents, antibiotics, heat, too much salt, toxic metals, and the immune systems of animals that they infect. Bacterial cells can do many things to protect themselves from such stresses including detoxifying or eliminating the cause of stress or by changing some aspect of their physiology (not unlike how a human sweats when they are hot). Not all environments are equal and the way a bacterial cell survives in one environment may be detrimental in another. Bacteria have therefore evolved to link particular stress responses to cues they detect in their local environment. The details of what signals are being sensed and exactly how this information is integrated into an effective response is the focus of this research.