Deciphering the Regulation and Functional Mechanisms of the Type Three Secretion Apparatus

破译三型分泌器的调节和作用机制

• 批准号: RGPIN-2016-05587
• 负责人: CampbellValois, FrançoisXavier
• 金额: $ 2.26万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629722
• 关键词: Deciphering; Regulation; Functional; Mechanisms; Type

Many bacterial pathogens affecting crops, livestock and humans use secretion systems to deliver potent virulence factors to their host. One of the most prevalent is the Type Three Secretion System (T3SS). T3SS are constituted of proteins acting as transcription regulators, chaperones and effectors, and of a syringe-like nanomachine known as the Type Three Secretion Apparatus (T3SA), which transfer effectors upon contacting host cells. The latter phenomenon is the key element of the virulence potential of many human enteropathogens (e.g.

许多影响农作物、牲畜和人类的细菌病原体利用分泌系统向宿主传递强大的毒力因子。其中最普遍的是三型分泌系统(T3SS)。T3SS由作为转录调节因子、伴侣和效应器的蛋白质以及被称为T3SA的注射器状纳米机器组成，T3SA在与宿主细胞接触时转移效应器。后一种现象是许多人类肠道病原体毒力潜力的关键因素(例如