Identification and molecular dissection of novel host and viral factors for the spatiotemporal control of Flaviviridae RNA metabolism

用于黄病毒科 RNA 代谢时空控制的新型宿主和病毒因子的鉴定和分子解剖

• 批准号: RGPIN-2016-05584
• 负责人: ChatelChaix, Laurent
• 金额: $ 2.26万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629757
• 关键词: Identification; molecular; dissection; novel; host

In order to rapidly and efficiently respond to their environment and their needs, cells have evolved to both locally and temporally modulate gene expression at the posttranscriptional level. This can be achieved through the combined regulation of messenger RNA splicing, trafficking, stability and translation. However, how the cell orchestrates in time and space RNA metabolism through modulatory molecular switches remains poorly understood. As demonstrated many times in the history of biology, fundamental virology can often provide many answers to important molecular biology questions. In this respect, RNA viruses

为了快速有效地对环境和自身需求做出反应，细胞已经进化到在转录后水平上局部和暂时调节基因表达。这可以通过信使RNA剪接、转运、稳定性和翻译的联合调控来实现。然而，细胞如何通过调节分子开关在时间和空间上协调RNA代谢仍然知之甚少。正如生物学历史上多次证明的那样，基础病毒学通常可以为重要的分子生物学问题提供许多答案。在这方面，RNA病毒