Expression and function of GPCRs in the pregnant uterus

GPCRs在妊娠子宫中的表达和功能

• 批准号: RGPIN-2017-04141
• 负责人: Slater, Donna
• 金额: $ 1.89万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629855
• 关键词: Expression; function; GPCRs; pregnant; uterus

BACKGROUND: During pregnancy, the uterus undergoes profound changes both physically as it expands to house the growing baby, and biochemically as many hormonal signals help keep the uterus in a quiescent (relaxed) state until delivery. One group of, hormone like, chemical mediators thought to be important during pregnancy and labour, are the prostaglandins. Since prostaglandin levels rise though pregnancy, especially toward term, these mediators are widely implicated in the stimulation of uterine contractions and the remodeling events necessary for delivery. However, it is not clear whether prostaglandins trigger labour or if the observed increased is simply a consequence of labour being initiated by other factors. Labour is complex and likely to involve numerous factors. Research in my laboratory, focusses on the role of the prostaglandins, and how these may act via interaction with their receptors to promote quiescence during pregnancy and regulate contractions in the pregnant uterus. As the myometrial smooth muscle cells are the contractile component of the uterus, we will use these as a model to study the interactions and pathways of the prostaglandins and their receptors.

背景技术背景：在怀孕期间，子宫在物理上经历了深刻的变化，因为它扩展到容纳成长中的婴儿，并且在生物化学上，许多激素信号有助于保持子宫处于静止（放松）状态，直到分娩。一组激素样的化学介质被认为在怀孕和分娩期间是重要的，是三兰定。由于前列腺素水平在妊娠期间升高，特别是接近足月时，这些介质广泛参与刺激子宫收缩和分娩所需的重塑事件。然而，目前尚不清楚是阿托兰定引发了分娩，还是观察到的增加仅仅是其他因素引发分娩的结果。劳动是复杂的，可能涉及许多因素。在我的实验室的研究，重点是对三尖杉酯碱的作用，以及这些如何通过与其受体的相互作用，以促进怀孕期间的静止和调节怀孕子宫的收缩。由于子宫肌层平滑肌细胞是子宫的收缩成分，我们将使用这些作为模型来研究的相互作用和途径的三尖杉酯碱及其受体。