Coordination of cell cycle, metabolism, and myeloid differentiation by lineage-specific transcription factors

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A central problem in biology is to understand how cells and organisms regulate cell division in response to developmental and environmental cues. During blood cell development, quiescent hematopoietic stem cells generate rapidly proliferating progenitor cells. As progenitor cells differentiate into mature cells, they gradually slow the rate of their cell cycle clock and induce changes in gene expression. There is emerging evidence that metabolic changes during hematopoietic differentiation are an important input into the cell cycle clock. This differentiation process is under the control of cell-type-specific transcription factors. Much remains to be learned about mechanisms by which cell type specific transcription factors coordinate cell cycle arrest with differentiation.