Coordination of cell cycle, metabolism, and myeloid differentiation by lineage-specific transcription factors

通过谱系特异性转录因子协调细胞周期、代谢和骨髓分化

• 批准号: RGPIN-2016-04749
• 负责人: DeKoter, Rodney
• 金额: $ 2.26万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629878
• 关键词: Coordination; cell; cycle; metabolism; myeloid

A central problem in biology is to understand how cells and organisms regulate cell division in response to developmental and environmental cues. During blood cell development, quiescent hematopoietic stem cells generate rapidly proliferating progenitor cells. As progenitor cells differentiate into mature cells, they gradually slow the rate of their cell cycle clock and induce changes in gene expression. There is emerging evidence that metabolic changes during hematopoietic differentiation are an important input into the cell cycle clock. This differentiation process is under the control of cell-type-specific transcription factors. Much remains to be learned about mechanisms by which cell type specific transcription factors coordinate cell cycle arrest with differentiation.

生物学的一个中心问题是了解细胞和生物体如何调节细胞分裂以响应发育和环境线索。在血细胞发育期间，静止的造血干细胞产生快速增殖的祖细胞。随着祖细胞分化为成熟细胞，它们逐渐减慢细胞周期时钟的速率并诱导基因表达的变化。有新的证据表明，造血分化过程中的代谢变化是细胞周期时钟的重要输入。这种分化过程是在细胞类型特异性转录因子的控制下。关于细胞类型特异性转录因子协调细胞周期停滞与分化的机制，还有很多有待了解。