Defining the Role of Staufen proteins in pre-mRNA Splicing

定义诗道芬蛋白在前 mRNA 剪接中的作用

• 批准号: RGPIN-2017-05313
• 负责人: Côté, Jocelyn
• 金额: $ 1.89万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629911
• 关键词: Defining; Role; Staufen; proteins; pre

Each of our cells contain in their nucleus the exact same genetic information, encoded into our DNA. However, most of our cells have distinct roles and functions in our body, as they can be part of very distinct tissues (for example, the cells from your liver are very different from the cells in your brain). It is therefore how this genetic information is decoded and processed that will vary from cells to cells, and in turn, this is largely how the incredible cellular diversity and tissue complexity is created in our body. This decoding of genetic information, which we call ‘gene expression’ involves several steps and generates many intermediates along the way (including molecule known as ‘messenger RNAs or mRNAs’). The first step of gene expression is transcription, and it is by far the most studied. Our research group is interested in steps of gene expression that are after transcription, and that are thus referred to as ‘post-transcriptional processes’.

我们每个细胞的细胞核中都含有完全相同的遗传信息，编码到我们的DNA中。然而，我们的大多数细胞在我们的身体中有不同的角色和功能，因为它们可以是非常不同的组织的一部分（例如，肝脏细胞与大脑细胞非常不同）。因此，这种遗传信息是如何解码和处理的，这将因细胞而异，反过来，这在很大程度上是如何在我们体内创造令人难以置信的细胞多样性和组织复杂性的。这种遗传信息的解码，我们称之为“基因表达”，涉及几个步骤，并在此过程中沿着产生许多中间产物（包括称为“信使RNA或mRNA”的分子）。基因表达的第一步是转录，这是迄今为止研究最多的。我们的研究小组对转录后的基因表达步骤感兴趣，因此被称为“转录后过程”。