Reindeer Antler Velvet: a unique model to study cellular and molecular mechanisms underlying tissue regeneration

驯鹿鹿茸：研究组织再生的细胞和分子机制的独特模型

• 批准号: RGPIN-2017-04825
• 负责人: Biernaskie, Jeffrey
• 金额: $ 2.48万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630091
• 关键词: Reindeer; Antler; Velvet; unique; model

Mammalian evolution has selected for accelerated wound closure at the expense of generating fibrotic scar. To enable future development of therapies that improve skin healing, a comprehensive understanding of the molecular signals that promote a regenerative versus fibrotic healing response will be essential. Our current understanding of these divergent processes is poor, partly because we lack a robust mammalian model of tissue regeneration.

哺乳动物进化选择了加速伤口闭合，代价是产生纤维化瘢痕。为了使未来能够开发改善皮肤愈合的疗法，全面了解促进再生与纤维化愈合反应的分子信号将是必不可少的。我们目前对这些不同过程的理解很差，部分原因是我们缺乏一个强大的哺乳动物组织再生模型。