Investigation of Central Nervous System synaptogenesis

中枢神经系统突触发生的研究

• 批准号: RGPIN-2015-06582
• 负责人: Bouchard, JeanFrançois
• 金额: $ 4.15万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630561
• 关键词: Investigation; Central; Nervous; System; synaptogenesis

During neural development, precise connections must form between neurons and their targets for the proper function of the mature Central Nervous System. The wiring of this network is strongly linked to axon guidance. Axons have to travel on long distance and connect to their specific targets. The formation of synapses is also crucial to development, maturation, and remodeling of the Central Nervous System (CNS). Identifying the mechanisms involved in their formation and stabilization remains a fundamental question.

在神经发育过程中，神经元和它们的目标之间必须形成精确的连接，以使成熟的中枢神经系统正常运作。这个网络的布线与轴突导向密切相关。轴突必须长距离移动并连接到特定的目标。突触的形成对中枢神经系统（CNS）的发育、成熟和重塑也至关重要。确定其形成和稳定的机制仍然是一个根本问题。