Biology of the Nutraceutical L-Citrulline

营养保健品 L-瓜氨酸的生物学

• 批准号: RGPIN-2015-04946
• 负责人: Ussher, JohnEdward
• 金额: $ 2.11万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630573
• 关键词: Biology; Nutraceutical; Citrulline

L-citrulline (LC) is an a-amino acid synthesized from L-ornithine and carbamoyl phosphate in the Urea Cycle via ornithine carbamoyltransferase, while it also serves as a by-product of the nitric oxide (NO) synthase (NOS) reaction, which converts L-arginine into LC and NO. Of interest, LC can be purchased over the counter as a dietary supplement. Studies in humans have shown that LC may act as a performance enhancer, however, the biological actions of LC, and the mechanisms by which LC may enhance performance have been relatively understudied.

L-瓜氨酸 (LC) 是一种 a-氨基酸，由 L-鸟氨酸和氨基甲酰磷酸在尿素循环中通过鸟氨酸氨基甲酰基转移酶合成，同时它也是一氧化氮 (NO) 合酶 (NOS) 反应的副产物，该反应将 L-精氨酸转化为 LC 和 NO。有趣的是，LC 可以作为膳食补充剂在柜台购买。对人体的研究表明，LC 可以作为运动表现增强剂，然而，LC 的生物作用以及 LC 增强运动表现的机制尚未得到充分研究。