The acetylcholine-gated chloride channel gene family in parasitic nematodes

寄生线虫中乙酰胆碱门控氯离子通道基因家族

• 批准号: RGPIN-2015-05284
• 负责人: Forrester, Sean
• 金额: $ 1.75万
• 依托单位: University of Ontario Institute of Technology
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630598
• 关键词: acetylcholine; gated; chloride; channel; gene

Infection with parasitic nematodes causes considerable disease burden in developing countries as well as North America.  Currently, the only method of control is through the use of nematocides.  However, despite the significant disease burden for both humans and domestic animals and rising incidences of drug resistance there are relatively few treatments available.  Therefore, the discovery and characterization of new nematocidal targets to both reduce the morbidity caused by human parasites as well as maintain the control of parasites of livestock will have far reaching global implications.  The recent completion of several parasitic nematode genomes has now provided an opportunity to begin a comprehensive search for potential new and unique nematocidal targets while at the same time increasing our understanding of the biology of these important pathogens. There is a large family of receptors called cys-loop receptors that have good potential as targets for new nematocides since they are important for the nervous system of parasitic nematodes and several members of this family are found only in invertebrates.

寄生线虫感染在发展中国家和北美造成了相当大的疾病负担。 目前，唯一的控制方法是通过使用杀线虫剂。 然而，尽管人类和家畜的疾病负担很重，耐药性的发生率也在上升，但可用的治疗方法相对较少。 因此，发现和表征新的杀线虫靶标以降低由人类寄生虫引起的发病率以及保持对家畜寄生虫的控制将具有深远的全球影响。 最近完成的几个寄生线虫基因组现在提供了一个机会，开始全面搜索潜在的新的和独特的杀线虫的目标，同时增加我们对这些重要的病原体的生物学的理解。存在称为cys环受体的受体大家族，其具有作为新杀线虫剂的靶标的良好潜力，因为它们对于寄生线虫的神经系统是重要的，并且该家族的几个成员仅在无脊椎动物中发现。