Neurobiological regulation of extinction learning in appetitve conditioning

食欲调节中消退学习的神经生物学调节

• 批准号: RGPIN-2017-04802
• 负责人: Chaudhri, Nadia
• 金额: $ 1.82万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630661
• 关键词: Neurobiological; regulation; extinction; learning; appetitve

The capacity to inhibit actions and reactions when an anticipated environmental stimulus no longer occurs is critical for flexible, adaptive behaviour. The ensuing decrement in conditioned responding, referred to as extinction, has been extensively researched using aversive Pavlovian conditioning procedures in which a conditional stimulus (CS) is paired with a noxious unconditional stimulus (US), and then the US is withheld to induce extinction. Results suggest that extinction produces a new inhibitory memory that competes with the original learning for control over responding. Specifically, a new CS-no US memory is formed during extinction that competes with the original CS-US memory to suppress responding.

当预期的环境刺激不再发生时抑制行为和反应的能力对于灵活、适应性行为至关重要。随之而来的条件反应的减少，称为灭绝，已经使用厌恶的巴甫洛夫条件反射程序进行了广泛的研究，其中条件刺激（CS）与有害的无条件刺激（US）配对，然后抑制 US 来诱导灭绝。结果表明，消退产生了一种新的抑制性记忆，它与原始学习竞争，以控制反应。具体来说，在消退过程中会形成新的 CS-no US 记忆，与原始的 CS-US 记忆竞争以抑制响应。