Maturation of Circuits Underlying Learning and Memory

学习和记忆回路的成熟

• 批准号: RGPIN-2017-06344
• 负责人: ArrudaCarvalho, Maithe
• 金额: $ 2.4万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630741
• 关键词: Maturation; Circuits; Underlying; Learning; Memory

Our perceptual, cognitive and emotional abilities emerge at specific times during development and are critically shaped by experiences that occur during early life. Early development is also a period during which key brain areas involved in emotional processing, such as the hippocampus and prefrontal cortex, are maturing. This maturation coincides with the emergence of behaviours dependent on hippocampus-prefrontal cortex networks, such as the ability to generate long lasting memories, or memory persistence. Despite convergent evidence of volumetric, structural, and synaptic changes taking place in prefrontal cortex and hippocampus at the same time as memory persistence emerges,

我们的感知、认知和情感能力在发育的特定时期出现，并受到早期生活经历的关键影响。早期发育也是大脑中涉及情绪处理的关键区域，如海马体和前额皮质，正在成熟的时期。这种成熟与依赖海马体-前额叶皮层网络的行为的出现是一致的，比如产生持久记忆的能力，或者记忆持久性。尽管越来越多的证据表明，在记忆持久性出现的同时，前额皮质和海马体的体积、结构和突触也发生了变化，