Cortical Circuits Underlying Functional Recovery Following Stroke

项目摘要 中风是美国长期残疾的主要原因之一。恢复 中风导致的残疾影响患者的长期生活质量。建议的目标 该项目旨在揭示中风后功能恢复的电路机制。我们将 采用创新的方法，使用最先进的双光子成像技术， 用光遗传学刺激小鼠。这些方法将使我们能够监控和操纵 同样的神经回路通过这些新方法，我们将测试 不同种类的神经元在中风恢复中具有不同的作用。我们 该方法将为确定更有效的促进卒中的干预措施提供基础 通过细胞类型特异性操作进行恢复。

Project Summary Stroke is one of the leading causes of long-term disability in the United States. Recovery from stroke-induced disability affects patients’ long-term quality of life. The goal of the proposed project is to unravel the circuit mechanisms underlying functional recovery after stroke. We will employ innovative approaches using state-of-the-art two-photon imaging techniques combined with optogenetic stimulation in mice. These approaches will allow us to monitor and manipulate the same neural circuits longitudinally. Through these novel approaches, we will test the hypothesis that different classes of neurons have different roles in stroke recovery. Our approach will provide the basis for identifying more effective interventions that promote stroke recovery through cell-type-specific manipulation.