Cortical Circuits Underlying Functional Recovery Following Stroke

中风后功能恢复的皮层回路

• 批准号: 10638607
• 负责人: Takashi Sato
• 金额: $ 37.75万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10638607
• 关键词: Address; Affect; Area; Axon; Behavior; Behavioral Paradigm; Brain; Cells; Consensus; Contralateral; Corpus striatum structure; Data; Electroporation; Enterobacteria phage P1 Cre recombinase; Future; Goals; Head; Image; Imaging Techniques; Interneurons; Investigation; Ipsilateral; Label; Left; Mediating; Monitor; Motor Cortex; Movement; Mus; Neurons; Parvalbumins; Patients; Pattern; Performance; Presynaptic Terminals; Process; Quality of life; Recovery; Recovery of Function; Rehabilitation therapy; Research; Role; Side; Site; Somatosensory Cortex; Somatostatin; Spinal Cord; Stroke; Testing; Time; Training; United States; Vasoactive Intestinal Peptide; Visualization; axonal sprouting; cell type; disability; effective intervention; frontal lobe; hippocampal pyramidal neuron; improved; in vivo calcium imaging; in vivo two-photon imaging; inhibitory neuron; innovation; motor recovery; neural circuit; novel strategies; optogenetics; post stroke; stroke recovery; two-photon

Project Summary Stroke is one of the leading causes of long-term disability in the United States. Recovery from stroke-induced disability affects patients’ long-term quality of life. The goal of the proposed project is to unravel the circuit mechanisms underlying functional recovery after stroke. We will employ innovative approaches using state-of-the-art two-photon imaging techniques combined with optogenetic stimulation in mice. These approaches will allow us to monitor and manipulate the same neural circuits longitudinally. Through these novel approaches, we will test the hypothesis that different classes of neurons have different roles in stroke recovery. Our approach will provide the basis for identifying more effective interventions that promote stroke recovery through cell-type-specific manipulation.

项目摘要 中风是美国长期残疾的主要原因之一。从 中风引起的残疾会影响患者的长期生活质量。提议的目标 项目是为了揭示中风后功能恢复的基础电路机制。我们将 员工创新方法使用最先进的两光子成像技术结合了 小鼠的光遗传刺激。这些方法将使我们能够监视和操纵 相同的中性圆圈纵向。通过这些新颖的方法，我们将测试 假设不同类别的神经元在中风恢复中具有不同的作用。我们的 方法将为识别促进中风的更有效干预措施提供基础 通过细胞型特异性操作恢复。