Mechanisms of rod and cone disk membrane synthesis and quality control in normal and diseased retina.

正常和患病视网膜中视杆和视锥盘膜合成的机制和质量控制。

• 批准号: 371288
• 负责人: Moritz Orson L
• 金额: $ 54.34万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=371288&lang=en
• 关键词: Codon Bias; Disk Membranes; Er Quality Control; Photoreceptors; Protein Folding; Retinal Degeneration; Retinitis Pigmentosa; Rhodopsin; Rods And Cones; Transgenic Animals

Retinal degenerative diseases are genetic disorders of the retina in which patients slowly lose their vision, resulting in blindness. Retinitis pigmentosa is a disorder causing death of rod photoreceptors, while other retinal degenerations affect both rod

视网膜退行性疾病是视网膜的遗传性疾病，患者会慢慢失去视力，导致失明。色素性视网膜炎是一种引起视杆光感受器死亡的疾病，而其他视网膜变性影响两种视杆