Regulation of nitrogen salvage in non-ruminants

非反刍动物氮回收的调控

• 批准号: RGPIN-2017-05275
• 负责人: Columbus, Daniel
• 金额: $ 1.89万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630898
• 关键词: Regulation; nitrogen; salvage; non; ruminants

Pigs and other non-ruminant animals are capable of salvaging nitrogen through the process of urea recycling and subsequent microbial amino acid production in the gastrointestinal tract. However, the regulatory mechanisms for urea recycling into the gut and the factors (e.g., dietary, physiological) influencing the extent of urea recycling and subsequent nitrogen utilization are not well understood. In the ruminant, it has been shown that urea transport into the rumen is due, in part, to facilitative urea transporters (UT-B and aquaporins) in addition to non-specific paracellular movement. Dietary factors, such as fibre and protein intake, may influence nitrogen salvage through altering the gut environment and changes in nutrient supply to the animal and resident microbes.

猪和其他非反刍动物能够通过尿素循环和随后在胃肠道中产生微生物氨基酸的过程来回收氮。然而，尿素再循环进入肠道的调节机制以及影响尿素再循环程度和随后的氮利用的因素(例如，饮食、生理)还不是很清楚。在反刍动物中，已证明尿素进入瘤胃的部分原因是由于尿素转运蛋白(UT-B和水通道蛋白)的易化，以及非特异性的细胞旁运动。膳食因素，如纤维和蛋白质摄入量，可能通过改变肠道环境和改变动物和寄生微生物的营养供应来影响氮的回收。