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AIDS Malignancy Clinical Trials Consortium

艾滋病恶性肿瘤临床试验联盟

基本信息

批准号：
7689546
负责人：
RONALD T. MITSUYASU
金额：
$ 2.5万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-29 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7689546
关键词：
1-Phosphatidylinositol 3-Kinase 11p 15q 20q 3q21 3q22.2 3q22.3 3q28 5-(6)-carboxyfluorescein diacetate succinimidyl ester 90Y AIDS Malignancy Consortium AIDS Vaccines AIDS and Cancer Specimen Bank AIDS chemotherapy AIDS clinical trial group AIDS diagnosis AIDS epidemiology AIDS related cancer AIDS related neoplasm AIDS therapy AIDS with Kaposi&apos s sarcoma AIDS-Related Burkitt&apos s Lymphoma AIDS-Related Disorder AIDS-Related Hodgkin&apos s Lymphoma AIDS-Related Lymphoma AIDS-Related Non-Hodgkin&apos s Lymphoma AIDS-Related Primary Central Nervous System Lymphoma Abbreviations Abdomen Aberrant DNA Methylation Ablation Academic Medical Centers Academy Accountability Accounting Acquired Immunodeficiency Syndrome Acute Acute T Cell Leukemia Address Adherence Adjuvant Administrator Adopted Adoptive Transfer Adrenal Cortex Hormones Adult Adult Burkitt&apos s Lymphoma Advanced Malignant Neoplasm Adverse effects Adverse event Advisory Committees Advisory Services Advocacy Advocate Affect Affinity Africa Africa South of the Sahara African African American African Burkitt&apos s lymphoma Aftercare Age Age-Years Aggressive behavior Aging Agreement Agriculture Alabama Aldesleukin Algorithms All Sites Allergic Reaction Alternative Medicine Amendment American American College of Surgeons American Society of Clinical Oncology Anal Intraepithelial Neoplasia Anal canal Anal carcinoma Anemia Anesthetics Angiogenesis Inhibition Angiogenesis Inhibitors Angiogenic Factor Annexins Anogenital Human Papilloma Virus Infection Anogenital cancer Anogenital venereal warts Anthracycline Antibiotics Anthracyclines Anti-Retroviral Agents Antibodies Antibody Affinity Anticonvulsants Antigen Targeting Antigens Antineoplastic Agents Antiretroviral resistance Antisense Oligonucleotides Antiviral Agents Antiviral Therapy Ants Anus Aplastic Anemia Apoptosis Apoptotic Appearance Appendix Applications Grants Appointment Archives Area Arginine Butyrate Arthralgia Arts Aryl Hydrocarbon Receptor Ascaridil Aspirate substance Asthenia Attention Australia Authorization documentation Autologous Autologous Stem Cell Transplantation Automobile Driving Award Azacitidine B Cell Proliferation B lymphoid malignancy B-Cell Activation B-Cell Lymphomas B-Cell Neoplasm B-Cell NonHodgkins Lymphoma B-Lymphocytes BCL2L1 gene BMS-275291 Bacterial Infections Basement membrane Basic Science Behavior Benchmarking Benefits and Risks Binding Bioavailable Biochemical Bioethics Bioinformatics Biologic Characteristic Biological Biological Assay Biological Factors Biological Markers Biology Biomedical Research Biometry Biopsy Biopsy Specimen Bisexual Blinded Blood Blood Cells Blood Platelets Blood Vessels Blood capillaries Blood donor Blood donor screening Blood specimen Bolus Infusion Bone Marrow Bone Marrow Diseases Bone Marrow Suppression Book Chapters Books Bortezomib Bos taurus Boston Bowen&apos s Disease Bowenoid Papulosis Boxing Brain Brassicaceae Brazil Breast Feeding British Columbia Bryostatin 1/Vincristine Budgets Burkitt Lymphoma Burn injury Business Rules Businesses Busulfan Bylaw Bypass CCI-779 CD3 Antigens CD34 gene CD4 Lymphocyte Count CD4 Positive T Lymphocytes CD8-Positive T-Lymphocytes CD8B1 gene CDE protocol-cyclophosphamide/doxorubicin/etoposide CHK gene CI-1040 COL-3 CT2103 CXCL13 gene CYP2D6 gene CYP3A4 gene Calendar California Cameroon Cancer Center Cancer Etiology Cancer Patient Cancer Research Project Cancer Therapy Evaluation Program Cancer Trials Support Unit Cancer Vaccines Cancer cell line Cancer-Related Condition Capital Capsid Carcinoma Carcinoma in Situ Cardiovascular system Caring Carmustine/Cisplatin/Etoposide Case Report Form Case Study Caspase Catalytic RNA Categories Catheters Cattle Cause of Death Cell Count Cell Cycle Cell Cycle Progression Cell Death Cell Fraction Cell Line Cell Nucleus Cell Proliferation Cell Survival Cells Cellular Immunity Censuses Central Nervous System Lymphoma Central Nervous System Prophylaxis Centrosome Cerebrospinal Fluid Certification Cervical Cervical Intraepithelial Neoplasia Cervical dysplasia Cervix Uteri Cervix carcinoma Cessation of life Cetuximab Chairperson Characteristics Charge Chelating Agents Chemicals Chemosensitization Chemotherapy-Oncologic Procedure Chicago Chickens Child Childhood Childhood Non-Hodgkin&apos s Lymphoma Chile Chimeric Proteins Chin China Choline Kinase Chromosomal Instability Chromosomal translocation Chromosome Arm Chromosomes Chromosomes, Human, Pair 8 Chronic Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia Cidofovir Cisplatin Cisplatin/Cytarabine/Etoposide/Methylprednisolone Cisplatin/Mitomycin Cities Civil Rights Class Classification Clinic Clinical Clinical Data Clinical Data Update System Clinical Engineering Clinical Ethics Clinical Investigator Clinical Management Clinical Protocols Clinical Research Clinical Research Associate Clinical Treatment Clinical Trials Clinical Trials Cooperative Group Clinical Trials Data Monitoring Committees Clinical Trials Design Clinical Trials Network Clinical effectiveness Clonal Expansion Clonality Cloning Closure Cluster Analysis Coagulation Process Coccidiosis Cocos Code Coffee Cohort Studies Coin Cold Therapy Collaborations Collagen Type I Collection Colon Colon Carcinoma Colon, Rectum Colorado Colorectal Colorectal Cancer Colostomy Procedure Colposcopy Combination Chemotherapy Combined Modality Therapy Combivir Combretastatin A-4 Combretastatin A4 Disodium Phosphate Combretastatin A4 Phosphate Commerce Commit Committee Members Committee Membership Common Data Element Common Terminology Criteria for Adverse Events Communicable Diseases Communication Communities Community Clinical Oncology Program Community Outreach Community Physician Community Relations Companions Comparative Study Complementary DNA Completion Status Complex Comprehensive Cancer Center Computer Systems Computer Systems Development Computer software Computers Condition Conduct Clinical Trials Confidence Intervals Confidential Information Confidentiality of Patient Information Conflict (Psychology)Conflict of Interest Conjunctival Squamous Cell Carcinoma Consensus Consent Consent Forms Consultations Continuous Ambulatory Peritoneal Dialysis Continuous Infusion Contract Services Contracts Controlled Study Contusions Core Facility Correlation Studies Correlative Study Cosmetics Cost Allocation Cost Sharing Counseling Count Country County Couples Cream Cremophor Cross-Sectional Studies Cutaneous Cutaneous Involvement Cyclin D1 Cyclophosphamide Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Vincristine Cyclosporins Cytarabine Cytidine Deaminase Cytochrome P450 Cytology Cytology Histology Cytomegalovirus Cytomegalovirus Retinitis Cytotoxic Chemotherapy Cytotoxic T-Lymphocytes DM-Et DNA DNA Fingerprinting DNA Integration DNA Sequence DNA Sequence Rearrangement DNA copy number DNA-Directed DNA Polymerase Daily Data Data Analyses Data Collection Data Quality Data Reporting Data Set Databases Death Rate Debridement Decision Making Decision Support Systems Defect Defective spinal cord development Deglutition Disorders Dementia Dental Research Deoxyribonuclease I Deoxyribonucleases Deposition Derivation procedure Dermal Dermatologic Detection Developed Countries Developing Countries Development Development Plans Developmental Therapeutics Program Devices Diagnosis Diagnostic Diagnostic Imaging Diagnostic Neoplasm Staging Diagnostic Procedure Diarrhea Didanosine Differentiation Antigens Diffuse Diffuse Large-Cell Lymphoma Digestion Digit structure Digital Rectal Examination Direct Costs Disabled Persons Discrimination Disease Disease Outcome Disease Progression Disease regression Disease remission Disease-Free Survival Disorder by Site Disputes Disruption Disseminated eosinophilic collagen disease Distant District of Columbia Docetaxel/Thalidomide Doctor of Medicine Doctor of Philosophy Documentation Dominant-Negative Mutation Dose Dose-Limiting Double-Blind Method Down-Regulation Doxorubicin Doxorubicin/Etoposide Doxorubicin/Methotrexate Doxorubicin/Paclitaxel Drops Drug Approval Drug Delivery Systems Drug Evaluation Drug Formulations Drug Interactions Drug Kinetics Drug abuse Drug resistance Drug usage Dysmyelopoietic Syndromes Dysplasia E-Selectin EBV-associated malignancy EGF gene ESHAP regimen Early treatment Eastern Cooperative Oncology Group Edema Education Educational workshop Effectiveness Effectiveness of Interventions Electrocoagulation Electronics Elements Eligibility Determination Emergency Situation Emerging Communicable Diseases Employee Encapsulated End Point Endocrinology Endopeptidases Endothelial Cells Endpoint Determination Enrollment Ensure Environment Environment Design Enzyme-Linked Immunosorbent Assay Enzymes Epidemic Epidemiologic Studies Epidemiologist Epidemiology Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Epithelial Epithelial Cells Epithelial ovarian cancer Epithelium Epstein-Barr Virus Infections Epstein-Barr Virus latency Epstein-Barr Virus-Related Lymphoma Equipment Equipment and supply inventories ErbB Receptor Family Protein Erythrocytes Erythropoietin Estrogens Etanercept Ethicists Ethics Etiology Etoposide Etoposide/Ifosfamide Europe Evaluation Evaluation Reports Event Evidence Based Medicine Evolution Exanthema Excision Exhibits Exons Expenditure Exposure to Extracellular Matrix Extracellular Signal Regulated Kinases Extramural Activities Extranodal Eye diseases Face Facilities and Administrative Costs Faculty Failure Family Family member Farming environment Fatigue Feedback Fees Female Fetus Fever Fibrinogen Fibroblast Growth Factor Fibroblast Growth Factor 2 Figs - dietary Filgrastim Financial compensation Florida Flow Cytometry Flowers Fluorouracil Focus Groups Follow-Up Studies Forensic Medicine Formalin Fostering Foundations Foxes France Fraud Freezing Frequencies Friends Fringe Benefit Functional disorder Funding Funding Agency Funding Mechanisms Funding Opportunities Future G-Protein-Coupled Receptors Gamma Rays Ganciclovir Ganciclovir/Interleukin-2/Zidovudine Gastrointestinal Neoplasms Gastrointestinal Stromal Tumors Gays Gel Gelatinase A Gelatinase B Gender Gene Expression Gene Expression Profiling Gene Targeting Gene Transfer Gene-Modified General Hospitals General Population Generations Generic Drugs Genes Genetic Genetic Polymorphism Genetic Transcription Genome Genomic Instability Genomics Genotype Genus Capra Genus Cola Geography Ghana Gills Glare Glass Gleevec Glycolysis Glycoproteins Goals Government Graft Rejection Grant Granulocyte Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Group Affiliation Group Meetings Growth Growth Factor Guidelines Gynecologic Oncologist Gynecologist Gynecology HIF1A gene HIV HIV prevention trials network HIV-1 Hair Half-Life Halofuginone Halofuginone Hydrobromide Hand Harvest Hawaii Head Head and Neck Cancer Head and Neck Squamous Cell Carcinoma Headache Health Health Insurance Portability and Accountability Act Health Sciences Health Services Research Healthcare Healthcare Systems Hearing Heating Helper-Inducer T-Lymphocyte Helsinki Declaration Hemangiosarcoma Hematologic Neoplasms Hematologist Hematology Hematopoietic Cell Growth Factors Hematopoietic Stem Cell Mobilization Hematopoietic stem cells Hemorrhage Hemorrhoids Hemosiderin Deposition Hepatic Hepatitis C virus Herpesviridae Herpesviridae Infections Heterosexuals High Prevalence Highly Active Antiretroviral Therapy Histologic Histology Histone Deacetylase Histone Deacetylase Inhibitor Histopathology Hodgkin Disease Holly Home environment Homologous Gene Homosexuals Hospital Departments Hospitals Hour Housing HspE7 Human Human Chorionic Gonadotropin Human Herpesvirus 4 Human Herpesvirus 8 Human Papillomavirus Human Resources Human T-lymphotropic virus 1 Human immunodeficiency virus test Human papilloma virus infection Human papillomavirus 16 Human papillomavirus 6 Humoral Immunities Hybrids Hydroxylation Hypergammaglobulinemia Hyperplasia Hypertension Hypoxia Hypoxia Inducible Factor IL2 gene IL6 gene Ibritumomab Tiuxetan IgE Image Imatinib Imatinib mesylate Imiquimod Immune Immune System Diseases Immune response Immune system Immunity Immunization Immunoblast Immunoblotting Immunocompetent Immunoglobulin A Immunoglobulin Class Switching Immunoglobulin G Immunoglobulin Somatic Hypermutation Immunoglobulin Variable Region Immunoglobulins Immunohistochemistry Immunologic Deficiency Syndromes Immunologic Markers Immunologics Immunologist Immunology Immunophenotyping Immunosuppression Immunotherapeutic agent Immunotherapy Implant In Situ Hybridization In Vitro In complete remission Incentives Incidence Incidence Study Income Indinavir Indinavir/Lamivudine/Stavudine Individual Induction of Apoptosis Industry Infant Infection Infectious Agent Inferior Inflammatory Information Dissemination Information Distribution Information Systems Information Technology Informed Consent Infusion procedures Injection Site Reaction Injection of therapeutic agent Institutes Institution Instruction Insulin-Like Growth Factor I Integral Membrane Protein Intention Interferon Alfa-2a Interferon Alfa-2b Interferon-alpha Interferons Interleukin 2 Receptor Interleukin 6 Receptor Interleukin-1 Interleukin-10 Interleukin-12 Interleukin-13 Interleukin-2 Interleukin-3 Interleukin-4 Interleukin-6 International International AIDS International Agency for Research on Cancer International Aspects International Prognostic Index International Unit Internet Intervention Intervention Studies Intraepithelial Neoplasia Intravenous Intravenous infusion procedures Invasive Investigation Investigational Drugs Ireland Island Isotretinoin Israel JNK-activating protein kinase Joints Journal of the National Cancer Institute Journals Justice Kaposi Sarcoma Karnofsky Performance Status Kenya Kidney Kidney Diseases Kidney Failure Kidney Transplantation Knowledge Label Laboratories Laboratory Research Laboratory Study Lactate Dehydrogenase Lamivudine/Zidovudine Laparotomy Large-Cell Immunoblastic Lymphoma Large-Cell Lymphomas Lasers Latin America Laws Lawyers Lead Leadership Learning Left Legal patent Length Lesion Lesion by Stage Letters Leucovorin Libraries Licensing Life Life Cycle Stages Ligands Ligation Light Lightheadedness Link Liposomal Doxorubicin Liposomes Liquid substance Literature Liver Dysfunction Liver Function Tests Lobbying Location Logistics Long-Term Effects Los Angeles Low Prevalence Lung Lung Kaposi&apos s Sarcoma Lymphatic Lymphatic Endothelium Lymphocyte Lymphocyte Activation Lymphocyte Count Lymphocyte Function Lymphocyte antigen Lymphoid Lymphoma Lymphomagenesis Lymphopenia Lymphoproliferative Disorders Lytic Lytic Phase MAP Kinase Gene MAPK14 gene MEKs MME gene MS4A1 gene Magnetic Resonance Imaging Mails Maintenance Maize Malawi Malignant - descriptor Malignant Neoplasms Malignant Squamous Cell Neoplasm Malignant lymphoid neoplasm Malignant neoplasm of anus Malignant neoplasm of cervix uteri Malignant neoplasm of gastrointestinal tract Malignant neoplasm of lung Malignant neoplasm of ovary Manuals Manuscripts Marrow Maryland Massachusetts Matrix Metalloproteinase Inhibitor Matrix Metalloproteinases Maximum Tolerated Dose Measurement Measures Mediating Mediation Medical Medical History Medical Oncologist Medical Oncology Medical Records Medical Research Medical center Medicine Melanocytic nevus Meleagris gallopavo Membrane Proteins Memorial Sloan-Kettering Cancer Center Mental Health Mentors Messenger RNA Metabolic Metabolic Clearance Rate Metabolic Pathway Metadata Methodology Methods Methotrexate Methylation Microarray Analysis Microbiology Mid-Career Clinical Scientist Award (K24)Mind Minor Minority Mission Mitogen-Activated Protein Kinase Inhibitor Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Mitogens Mitomycin Mitotic Mitotic spindle Modality Modeling Mole the mammal Molecular Molecular Biology Molecular Epidemiology Molecular Profiling Molecular Target Monitor Monoclonal Antibodies Monoclonal Antibody C225 Mononuclear Moods Morbidity - disease rate Mosses Mucositis Multi-Institutional Clinical Trial Multicenter Studies Multicenter Trials Multicentric Angiofollicular Lymphoid Hyperplasia Multidrug Resistance Gene Multinational Perspectives Multiple Myeloma Multivariate Analysis Mus Mutation Mycobacterium bovis Mycobacterium heat-shock protein 65 Mycoses Myelogenous Myelopoiesis Myelosuppression Myelosuppressive Therapy N(delta)-acetylornithine, -isomer N-dodecanoylglutamic acid, -isomer, sodium salt NF-kappa B Names Nasopharynx Carcinoma National Cancer Institute National Institute of Allergy and Infectious Disease National Institute of Mental Health Natural History Natural Killer Cells Nature Needles Needs Assessment Neoadjuvant Therapy Neoplasms Neurologic Neurology Neuropathy Neutropenia New Agents New York New York City Newly Diagnosed Newsletter Newspapers Nitrogen Nodal Nodular Lesion Non-Hodgkin&apos s Lymphoma Non-Small-Cell Lung Carcinoma None or Not Applicable Normal tissue morphology North Carolina Not Defined Notification Nuclear Nucleosides Nude Mice Numbers Nurses Nursing Research Object Attachment Obstetrics Departments Occupational activity of managing finances Office Management Office of Management Ohio Ointments Okadaic Acid Oligonucleotides Oncogene Activation Oncogene Proteins Oncogenes Oncogenic Oncogenic Viruses Oncologist Oncology Group Online Systems Open Reading Frames Operating Rooms Operative Surgical Procedures Opportunistic Infections Oral Organ Organ Transplantation Other Agency or Organization Other Working Groups Outcome Outcome Measure Outcome Study Outpatients Oxygen PDGF inhibition PDGFRB gene PIK3CA gene PIK3CB gene PTPRC gene Paclitaxel Pain Palate Kaposi&apos s Sarcoma Palpable Paper Papillomavirus Paraffin Embedding Paraffin Tissue Parents Partial Remission Participant Pathogenesis Pathologic Pathologist Pathology Pathway interactions Patient Care Patient Monitoring Patient Recruitments Patient currently pregnant Patients Pattern Patterns of Care Pediatric Hospitals Peer Review Pennsylvania Peptide Hydrolases Peptides Performance Peripheral Blood Mononuclear Cell Peripheral Nervous System Diseases Personal Communication Personal Satisfaction Persons Pharmaceutical Preparations Pharmacia brand of cidofovir Pharmacists Pharmacodynamics Pharmacologic Substance Pharmacology Phase Phase I Clinical Trials Phase I/II Trial Phase II Clinical Trials Phase III Clinical Trials Phenotype Phorbol Esters Phosphatidylinositols Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide Phosphorylation Phosphotransferases Photochemotherapy Photosensitivity Physician Executives Physicians Physiologic pulse Pigmentation physiologic function Pike fish Pilot Projects Placebo Control Placebos Planet Mars Plasma Platelet Count measurement Platelet-Derived Growth Factor Platelet-Derived Growth Factor Receptor Play Pliability Podophyllotoxin Poland Policies Polyarthritides Polymerase Polymerase Chain Reaction Polymers Population Population Control Population Group Population Study Populations at Risk Positioning Attribute Positron-Emission Tomography Poverty Pre-study Precancerous Conditions Predictive Factor Predisposition Prednisone Pregnancy Pregnancy Tests Premalignant Premedication Preparation Presbyterian Church Press Releases Prevalence Prevalence Study Prevention Prevention approach Prevention strategy Preventive Primary Care Physician Primary Health Care Primary Neoplasm Primary carcinoma of the liver cells Principal Investigator Printing Prior Chemotherapy Procedures Process Procollagen-Proline Dioxygenase Proctitis Production Productivity Professional counselor Prognostic Factor Prognostic Marker Program Research Project Grants Program Reviews Progress Reports Progression-Free Survivals Progressive Disease Proliferating Proline Property Prophylactic treatment Prospective Studies Prostate Adenocarcinoma Protease Inhibitor Proteasome Inhibitor Protein Isoforms Protein Kinase C Protein Overexpression Protein Tyrosine Kinase Proteins Proteolysis Proteomics Proto-Oncogene Protein c-kit Proto-Oncogene Proteins c-akt Proto-Oncogenes Protocols documentation Provider Psychiatrist Psychiatry Public Health Publications Published Comment Publishing Pulse taking Punch Biopsy Puncture procedure Purpose Qualifying Quality Control Quality of life Questionnaires RNA Radiation Radiation Therapy Oncology Group Radiation therapy Radio Radioimmunotherapy Radioisotopes Rana Randomized Randomized Controlled Clinical Trials Randomized Controlled Trials Range Rate Reaction Reading Rebeccamycin Analogue Receptor Inhibition Receptor Protein-Tyrosine Kinases Receptors, Antigen, B-Cell Recombinant Granulocyte Colony Stimulating Factor Recombinant Interferon Alfa Recombinant Interleukin-2 Recombinant Proteins Recombinants Recommendation Recording of previous events Records Recovery Recruitment Activity Rectum Recurrence Red Cross Refractory Registries Regression Analysis Regulation Relapse Relative (related person)Relative Risks Report (document)Reporting Reproduction Research Research Activity Research Contracts Research Design Research Ethics Research Ethics Committees Research Infrastructure Research Methodology Research Misconduct Research Personnel Research Priority Research Project Grants Research Subjects Research Support Research Training Residual Tumors Residual state Resistance Resistance development Resolution Resource Allocation Resource Sharing Resources Respiratory Failure Respiratory Insufficiency Rest Restart Retinoids Retrospective Studies Retroviridae Reverse Transcriptase Inhibitors Reverse Transcriptase Polymerase Chain Reaction Review Committee Review Literature Rheumatoid Arthritis Rights Risk Risk Factors Risk Marker Ritonavir Role Rolfing Room, Clean Rosa Rotation Route Running Russia Rwanda SCID Mice SGN-00101 (HspE7)STI571 SU 5416 Safety Salaries and Fringe Benefits Salvage Therapy Sample Size Sampling Sampling Studies San Francisco Satellite Viruses Schedule Science Score Scotland Screening for cancer Screening procedure Secondary to Secure Seminal Senior Scientist Sensitivity Training Groups Sensitivity and Specificity Sequence Analysis Series Serious Adverse Event Serodiagnoses Serologic tests Serological Seroprevalences Serum Services Severities Sex Functioning Sexually Transmitted Agents Sexually Transmitted Diseases Shipping Ships Side Signal Pathway Signal Transduction Signal Transduction Inhibitor Signal Transduction Pathway Significance Level Signs and Symptoms Simplexvirus Sirolimus Site Site Visit Skin Skin Kaposi&apos s Sarcoma Slide Small Business Funding Mechanisms Small Business Innovation Research Grant Small Business Technology Transfer Research Smoke Smoking History Societies Solid Solid Neoplasm Solutions Somatic Mutation Source South Africa Specialist Specialized Program of Research Excellence Specific qualifier value Specificity Specimen Specimen Handling Squamous Cell Squamous Cell Neoplasms Squamous cell carcinoma Squamous intraepithelial lesion Staging Staging System Staining method Stains Standards of Weights and Measures Statistically Significant Stem Cell Factor Stem Cell Research Stem cell transplant Sterilization for infection control Stomatitis Strategic Planning Stratification Structure Structure of germinal center of lymph node Students Study Section Study Subject Subgroup Suggestion Sum Supervision Supportive care Surface Surface Immunoglobulins Surgeon Survey Methodology Surveys Survival Rate Suspension substance Suspensions Sutent Swab Swelling Switzerland Symptoms Syncope Syndrome System T memory cell T-Lymphocyte TAF8 gene TNFRSF8 gene TNP470 TP53 gene TSC1/2 gene TSC2 gene Tampons Tanzania Taxane Compound TdT-Mediated dUTP Nick End Labeling Assay Techniques Technology Technology Transfer Teleconferences Telefacsimile Telephone Telephone Number Telomerase Temperature Testing Tetracycline Tetracyclines Textbooks Thalidomide Therapeutic Therapeutic Agents Therapeutic Clinical Trial Therapeutic Effect Therapeutic Human Experimentation Therapeutic Intervention Therapeutic Studies Therapeutic immunosuppression Therapy Clinical Trials Therapy Evaluation Thermography Thinking Thrombocytopenia Thymidine Thymidine Kinase Time TimeLine Tissue Banks Tissue Microarray Tissue Sample Tissue Survival Tissues Toll-like receptors Topical agent Topical application Touch sensation Toxic effect Training Training Programs Transactivation Transcript Transcription Factor AP-1 Transforming Growth Factor alpha Transforming Growth Factors Transfusion Translational Research Translations Transplant Recipients Transplantation Travel Treatment Efficacy Treatment Protocols Treatment outcome Triage Trichloroacetic Acid Tube Tuberculosis Tumor Bank Tumor Biology Tumor Burden Tumor Cell Invasion Tumor Cell Line Tumor Necrosis Factor-alpha Tumor Necrosis Factors Tumor Suppressor Proteins Tumor Tissue Tumor-Infiltrating Lymphocytes Turkey bird Type I Procollagen Tyrosine Kinase Inhibitor Ubiquitin Ubiquitination Uganda Ultrasonography Umbilical Cord Blood United States United States Dept. of Health and Human Services United States Food and Drug Administration United States National Institutes of Health Universities University Hospitals Up-Regulation Update Upper arm Ursidae Family VEGFC gene VHL protein Vaccinated Vaccination Vaginal Douching Validation Valproic Acid Variant Vascular Endothelial Cell Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor D Vascular Endothelial Growth Factor Receptor Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-2 Vascular Endothelial Growth Factor Receptor-3 Vascular Endothelial Growth Factors Vascular Permeabilities Vascular Proliferation Veins Velcade Vertebrates Veterans Vinblastine Vincristine Viral Viral Antigens Viral Genes Viral Load result Viral Markers Viral Oncogene Viral Pathogenesis Viral load measurement Viremia Virginia Virion Virus Virus Activation Virus Diseases Virus Latency Virus Replication Virus-Related Lymphoma Visceral Visible Radiation Vision Visit Vocabulary Von Hippel-Lindau Tumor Suppressor Protein Voting Vulnerable Populations Vulval intraepithelial neoplasia Wages Walkers Washington Water Web communication Week West Indies Widespread Disease Wolves Woman Women&apos s Group Women&apos s Health Wood material Work Workplace World Health Organization Writing Xenograft Model Xenograft procedure Xerostomia Xyotax Y 90 Ibritumomab Tiuxetan Yang Zea mays Zidovudine Zimbabwe absorption abstracting acquired immunodeficiency activation-induced cytidine deaminase adjudication age related alitretinoin alpha-difluoromethyl-DOPA, -isomer alpha-methylornithine dihydrochloride, -isomer anal canal Carcinoma analog angiogenesis antiangiogenesis therapy anticancer research antiretroviral therapy assay development astrin authority autocrine base bcr-abl Fusion Proteins birth control bleomycin/doxorubicin/vinblastine protocol bleomycin/doxorubicin/vincristine protocol bryostatin burden of illness c-erbB-1 Proto-Oncogenes c-myc Genes cancer Biomedical Informatics Grid cancer cell cancer diagnosis cancer immunotherapy cancer prevention cancer risk cancer therapy capillary capitate bone carcinogenesis career case-based cell growth cell killing cell mediated immune response cell type cellular targeting cervical and anal cancer chemokine chemotherapeutic agent chemotherapy child bearing cisplatin/fluorouracil protocol citrate carrier clinical efficacy clinical research site clinically significant cohort college comparative genomic hybridization comparative trial concept conjunctiva cooperative study cost cost effective cost effectiveness cyclin-dependent kinase inhibitor 1B cyclooxygenase 2 cyclophosphamide/doxorubicin protocol cyclophosphamide/prednisone/vincristine protocol cysteine rich protein cytokine cytopenia cytotoxic data acquisition data management data structure day demethylation demographics density design digital disability discontinuation trial disease natural history dosage doxorubicin/etoposide/vincristine protocol drug development drug distribution drug metabolism editorial efflux pump effusion expectation experience extracellular falls farmer follow-up foot forging frailty fundamental research gene therapy glucose metabolism granulocyte group counseling handbook handicapping condition healthy volunteer high throughput screening human FRAP1 protein human PIK3CA protein human TNF protein human embryonic stem cell human fetus tissue human prostaglandin D2 receptor human stem cells human subject hydroxyurea hypoxia inducible factor 1 immune function immunoregulation improved improved functioning in vivo indexing influenzavirus inhibitor/antagonist innovation inorganic phosphate insight instrument interest investigator training irinotecan irradiation kidney allograft killings kinase inhibitor large cell Diffuse non-Hodgkin&apos s lymphoma latency-associated nuclear antigen latent nuclear antigen lecturer lectures leukemia leukemia/lymphoma loris lymphoid hyperplasia lymphoid neoplasm lytic gene expression lytic replication macrophage male malignant breast neoplasm malignant mouth neoplasm mecarzole medical schools medical specialties melanoma member men men who have sex with men metastatic colorectal metastatic process microbicide migration molecular pathology monocyte mortality mouse model multicatalytic endopeptidase complex mycobacterial mycophenolate mofetil neoplasm registry neoplastic neoplastic cell neovascularization neutrophil news non-nucleoside reverse transcriptase inhibitors novel novel strategies novel therapeutics nucleoside analog older patient oncology optical imaging organizational structure outcome forecast ovarian neoplasm oxaliplatin p27 Cell Cycle Protein p27 Enzyme Inhibitor p65 pandemic disease paracrine parkin gene/protein partial response pathogen patient safety payment peer penis performance site peripheral blood pilot trial placebo controlled study platelet-derived growth factor BB pol genes posters pre-clinical preclinical study preconditioning prevent professor progenitor progesterone 11-hemisuccinate-(2-iodohistamine)prognostic programs promoter prospective protein expression protocol development quality assurance radiation resistance randomized placebo controlled trial ranpirnase receptor receptor downregulation receptor expression reconstitution repaired repository research and development research clinical testing research study response rituximab rural area sample collection sarcoma scalpel secretase sevin sex size skills skin discoloration skin disorder software development sound southern hybridization statistical center statistics stem study characteristics subcutaneous success symposium tat Protein taxane therapeutic target therapeutic vaccine therapy development tissue culture toe corn tool trafficking transcription factor translational study transmission process treatment duration treatment effect treatment trial trend tumor tumor growth tumor necrosis factor receptor superfamily, member 10b protein, mouse tumor progression tumor xenograft uptake urologic viral DNA viral RNA viral cyclin virology virus identification virus related cancer virus related neoplasm volunteer ward

项目摘要

DESCRIPTION (provided by applicant): The Group Chair' office of the AIDS Malignancy Consortium (AMC) is located in the UCLA Center for Clinical AIDS Research and Education (CARE Center), located at 9911 Pico Blvd, Ste 980, Los Angeles, CA 90035. The AMC is a clinical trials cooperative group established to evaluate new clinical interventions for the treatment and prevention of malignancies in HIV. The mission of the AMC is to improve the therapy of malignancies in HIV and to develop new and more effective treatment and prevention approaches. Dr. Ronald Mitsuyasu, the AMC Group Chair, is Director of the UCLA CARE Center and Professor of Medicine in the Division of Hematology-Oncology at UCLA. Dr. Mitsuyasu is responsible for the coordination, overall function, scientific direction, and fiscal accountability of the AMC. With input from the AMC working groups, Executive Committee and NCI Program Director, he sets the scientific agenda and oversees the execution of the AMC's protocols and other scientific endeavors. He chairs all meetings and conference calls of the Executive and Steering Committees, interacts with all components of the AMC and is the primary representative of the group to other oncology and HIV clinical trials groups, the AIDS Cancer and Specimen Resource (ACSR) and the NIAID Managing Partner Committee. Dr. Mitsuyasu will be assisted by a Project Manager who will coordinate the functions of the various group components and will maintain communications between the Group Chair and the sites, operations center, statistics center and core labs. She will also represent the Group Chair on working group calls and review protocols for accuracy and completeness prior to their being released to the sites. A project assistant will arrange and take minutes for all AMC conference calls and perform secretarial duties for the Group Chair and Project Manager. A project analyst will be responsible for monitoring all aspects of the finances of the group and preparing fiscal reports for the NCI. Malignancies are a growing problem in immune deficient HIV patients, and cancer remains one of the major causes of morbidity and mortality in AIDS patients. The AIDS Malignancy Consortium (AMC) conducts studies to improve the treatment of cancers in HIV disease. The AMC Group Chair's office is responsible for coordinating and overseeing all aspects of the functioning of the AMC.

描述（由申请人提供）：艾滋病联盟（AMC）的小组主席办公室位于加州大学洛杉矶分校临床艾滋病研究和教育中心（CARE中心），地址为9911皮科大道，街980，洛杉矶，CA 90035。 AMC是一个临床试验合作小组，旨在评估治疗和预防艾滋病毒恶性肿瘤的新临床干预措施。AMC的使命是改善艾滋病毒恶性肿瘤的治疗，并开发新的和更有效的治疗和预防方法。 AMC集团主席罗纳德Mitsuyasu博士是加州大学洛杉矶分校CARE中心主任，也是加州大学洛杉矶分校血液肿瘤学系医学教授。 Mitsuyasu博士负责AMC的协调、整体功能、科学方向和财务责任。在AMC工作组、执行委员会和NCI项目主任的帮助下，他制定科学议程，并监督AMC方案和其他科学工作的执行。他主持执行委员会和指导委员会的所有会议和电话会议，与AMC的所有组成部分互动，并且是该小组的主要代表，其他肿瘤学和HIV临床试验小组，艾滋病癌症和标本资源（ACSR）和NIAID管理合作伙伴委员会。Mitsuyasu博士将由一名项目经理协助，该项目经理将协调各小组成员的职能，并将保持小组主席与研究中心、运营中心、统计中心和核心实验室之间的沟通。她还将在工作组电话会议上代表小组主席，并在向研究中心发布之前审查方案的准确性和完整性。项目助理将安排所有AMC电话会议并做会议记录，并为集团主席和项目经理履行秘书职责。一名项目分析员将负责监测该集团财务的所有方面，并为NCI编写财务报告。在免疫缺陷的HIV患者中，恶性肿瘤是一个日益严重的问题，并且癌症仍然是AIDS患者发病率和死亡率的主要原因之一。艾滋病研究联盟（AMC）进行研究，以改善艾滋病毒疾病中的癌症治疗。AMC集团主席办公室负责协调和监督AMC运作的各个方面。