Quantitative microfluidic delivery systems for studying tissue microenvironment and microvascular blood flow regulation in vivo

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The nutritive requirements of all body tissues are provided for by the dynamic distribution of blood flow to microvascular networks throughout the body. Studying blood flow regulation in vivo requires specialized, minimally invasive, surgical preparations in order to isolate a tissue of interest while preserving the normal function and control of the regulatory system itself. We have previously developed gas exchange chambers to manipulate gas partial pressures in skeletal muscle of live rats. This work demonstrated the feasibility and efficacy of these devices and that the microcirculation can respond to changes in the surrounding microenvironment.