Circadian rhythm and the cerebral circulation

昼夜节律和脑循环

• 批准号: RGPIN-2017-04116
• 负责人: Braun, Andrew
• 金额: $ 2.33万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630988
• 关键词: Circadian; rhythm; cerebral; circulation

Circadian rhythms are oscillating biological processes that affect animal behavior (i.e. eating, sleeping), as well as major systems of the body (i.e. cardiovascular system). At the molecular level, circadian rhythms are driven by a core group of “clock genes” ” (i.e. Bmal1, CLOCK, Per and Cry) that evoke the rhythmic expression of target genes important for various physiological processes. Although the brain contains the central regulator of the body’s circadian rhythm, evidence indicates that peripheral cells and tissues exhibit their own intrinsic circadian rhythm, driven by the same cohort of molecular “clock” genes.

昼夜节律是影响动物行为（即进食，睡眠）以及身体主要系统（即心血管系统）的振荡生物过程。在分子水平上，昼夜节律是由一组核心的“时钟基因”（即Bmal 1、CLOCK、Per和Cry）驱动的，这些基因引起对各种生理过程重要的靶基因的节律性表达。虽然大脑包含身体昼夜节律的中央调节器，但有证据表明，外周细胞和组织表现出自己内在的昼夜节律，由同一组分子“时钟”基因驱动。