Circadian rhythm and the cerebral circulation

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Circadian rhythms are oscillating biological processes that affect animal behavior (i.e. eating, sleeping), as well as major systems of the body (i.e. cardiovascular system). At the molecular level, circadian rhythms are driven by a core group of “clock genes” ” (i.e. Bmal1, CLOCK, Per and Cry) that evoke the rhythmic expression of target genes important for various physiological processes. Although the brain contains the central regulator of the body’s circadian rhythm, evidence indicates that peripheral cells and tissues exhibit their own intrinsic circadian rhythm, driven by the same cohort of molecular “clock” genes.