Sensory and emotional processing in the human insula

人类脑岛的感觉和情绪处理

• 批准号: RGPIN-2016-05216
• 负责人: Nguyen, Dang
• 金额: $ 2.04万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=631119
• 关键词: Sensory; emotional; processing; human; insula

The insula is one of the least understood areas of the brain mostly due to its location: in the depth of the Sylvian fissure, which makes it less accessible and less susceptible to isolated injury than other cortical structures. Long solely viewed as a primitive ‘visceral brain’ structure, the insular cortex has gained much interest in the last decades with the advent of functional neuroimaging techniques, which have revealed insular responses to a wide variety of stimuli and paradigms. Functional domains that have been related to the insula include multisensory and pain processing, emotional experience, empathy and social cognition, motivation, and decision-making. However, the specific role of the insula in these functions remains uncertain. In the past 10 years, my team has contributed to the recognition of the insular cortex as a possible focus of epileptic seizures, and insular resections have been performed at our epilepsy centre in more than 30 patients with refractory epilepsy. We also perform direct exploration of the insula on a regular basis using intracranial electrodes to better delineate the epileptogenic zone when non-invasive techniques cannot, making it possible to study insular activity in response to various types of stimuli and tasks with very high temporal and spatial resolution. Access to this population provides us with an unprecedented opportunity to study the functions of the insular cortex in humans. The intent of this proposal is to provide a better understanding of the role of the human insula in sensory and emotional processing, using a combination of behavioral, electrophysiological, and neuroimaging techniques in patients with isolated insular injury as well as in healthy participants. Improving our comprehension of a brain area which has long been neglected is a fundamental issue belonging to the natural sciences. This program is focused on a single structure, the insula, which is involved in a variety of functions. By focusing on one of the least studied areas of the cerebral cortex, using the most state-of-the-art behavioral, electrophysiological, and neuroimaging techniques, this program has the potential to have a major impact on our understanding of brain function. Previous work by my group has already led to significant discoveries and expanded knowledge on the functions of the insula. The Discovery Grants from the NSERC would provide the funds necessary to take this research to a next level.

大脑皮层是大脑中最不为人所知的区域之一，这主要是由于它的位置：在大脑侧裂的深处，这使得它比其他皮质结构更不易接近，也更不易受到孤立损伤。长期以来，岛叶皮层一直被认为是一种原始的“内脏脑”结构，随着功能性神经成像技术的出现，岛叶皮层在过去的几十年里引起了人们的极大兴趣，这些技术揭示了岛叶对各种刺激和范式的反应。与脑电相关的功能领域包括多感觉和疼痛处理、情感体验、同理心和社会认知、动机和决策。然而，特派团在这些职能中的具体作用仍然不确定。在过去的10年里，我的团队为认识岛叶皮层作为癫痫发作的可能病灶做出了贡献，并且在我们的癫痫中心对30多名难治性癫痫患者进行了岛叶切除术。我们还定期使用颅内电极直接探查小脑延髓，以更好地描绘非侵入性技术无法描绘的致痫区，从而能够以非常高的时间和空间分辨率研究对各种类型刺激和任务的响应的岛叶活动。进入这个人群为我们提供了一个前所未有的机会来研究人类岛叶皮层的功能。本建议的目的是提供一个更好的理解的作用，人类大脑中的感觉和情绪处理，使用的行为，电生理学和神经影像学技术的组合在孤立的岛叶损伤患者以及健康的参与者。提高我们对长期被忽视的大脑区域的理解是属于自然科学的一个基本问题。这个程序是集中在一个单一的结构，在一个复杂的功能，这是涉及。通过专注于大脑皮层中研究最少的区域之一，使用最先进的行为，电生理和神经成像技术，该计划有可能对我们对大脑功能的理解产生重大影响。我的小组以前的工作已经导致了重大发现，并扩大了对大脑皮层功能的认识。NSERC的发现赠款将提供必要的资金，使这项研究更上一层楼。