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Defining the role of the histone 3 (H3.3G34R) mutation in the pathogenesis of pediatric high grade astrocytoma

Defining the role of the histone 3 (H3.3G34R) mutation in the pathogenesis of pediatric high grade astrocytoma
定义组蛋白 3 (H3.3G34R) 突变在儿童高级星形细胞瘤发病机制中的作用
批准号:
368929
负责人:
Hawkins Cynthia E
金额:
$69.66万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-09-01 至 2022-09-01

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中文摘要
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英文摘要
Brain tumors are the leading cause of cancer-related death in children and the most deadly of these are pediatric high grade astrocytomas (pHGA). We sequenced the entire genome of a large series of pHGAs and found frequent mutations in histone genes. Hist
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Next generation precision oncology for pediatric-type AYA gliomas
  • 批准号:
    462638
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    Operating Grants
  • 资助金额:
    $97.81万
  • 财政年份:
    2022
  • 负责人:
    Hawkins Cynthia E
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Investigating diffuse midline glioma evolution and treatment resistance
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    445320
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    $76.63万
  • 财政年份:
    2021
  • 负责人:
    Hawkins Cynthia E
  • 依托单位:
Molecular based approach for discovery and improved outcome for children and young adults with low grade glioma
  • 批准号:
    380722
  • 项目类别:
    Operating Grants
  • 资助金额:
    $68.55万
  • 财政年份:
    2018
  • 负责人:
    Hawkins Cynthia E
  • 依托单位:
Targeting Paediatric Brainstem Glioma Using Integrated Whole Genome Analysis
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    223922
  • 项目类别:
    Operating Grants
  • 资助金额:
    $42.36万
  • 财政年份:
    2011
  • 负责人:
    Hawkins Cynthia E
  • 依托单位:
海外基金