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Exploring the tumorigenesis of H3F3A mutations in pediatric high-grade astrocytoma (HGA) and Giant cell tumor of the bone (GCTB).

Exploring the tumorigenesis of H3F3A mutations in pediatric high-grade astrocytoma (HGA) and Giant cell tumor of the bone (GCTB).
探索儿童高级星形细胞瘤 (HGA) 和骨巨细胞瘤 (GCTB) 中 H3F3A 突变的肿瘤发生。
批准号：
377032
负责人：
Pratt Jonathan
金额：
$9.83万
依托单位：
McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-11-01 至 2020-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=377032&lang=en
关键词：
Biomarkers In Pediatric Cancers Cell Differentiation Processes Crispr Genome Editing System Genetic And Epigenetic Profiling H3f3a Mutations Mesenchymal Stem Cells Oncogenic Driver Mutations Pediatric Brain And Bone Cancers Rna-Seq And Chip-Seq T

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英文摘要
High-grade astrocytomas (HGAs) are aggressive brain tumors that have limited treatment options and very high mortality rates. One third of these tumors contain a particular genetic mutation in a protein called histone H3F3A which regulates the development
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