Development and application of cognitive neuroimaging tools for quantitative white matter analyses

用于定量白质分析的认知神经影像工具的开发和应用

• 批准号: RGPIN-2016-05954
• 负责人: Figley, Chase
• 金额: $ 2.04万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=631379
• 关键词: Development; application; cognitive; neuroimaging; tools

Quantitative white matter imaging methods such as diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), and myelin water imaging (MWI) are more sensitive than conventional MRI methods to changes in brain microstructure. However, despite advances in MRI hardware (e.g., higher magnetic field strengths and more receiver channels), improved data acquisition schemes (e.g., 3D pulse sequences and parallel imaging techniques), and the refinement of DTI, MTI and MWI acquisition parameters, data analysis approaches to quantify inter-subject differences and/or longitudinal changes in white matter structure have remained relatively static.

定量白色物质成像方法如扩散张量成像（DTI）、磁化传递成像（MTI）和髓磷脂水成像（MWI）比常规MRI方法对脑微结构的变化更敏感。然而，尽管MRI硬件（例如，更高的磁场强度和更多的接收器通道），改进的数据采集方案（例如，3D脉冲序列和并行成像技术），以及DTI、MTI和MWI采集参数的细化，量化受试者间差异和/或白色物质结构纵向变化的数据分析方法保持相对静态。