Development and application of cognitive neuroimaging tools for quantitative white matter analyses

点击翻译按钮获取中文摘要

Quantitative white matter imaging methods such as diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), and myelin water imaging (MWI) are more sensitive than conventional MRI methods to changes in brain microstructure. However, despite advances in MRI hardware (e.g., higher magnetic field strengths and more receiver channels), improved data acquisition schemes (e.g., 3D pulse sequences and parallel imaging techniques), and the refinement of DTI, MTI and MWI acquisition parameters, data analysis approaches to quantify inter-subject differences and/or longitudinal changes in white matter structure have remained relatively static.