Functions and interactions of brain areas hMT+ and hV4 in the human visual system

人类视觉系统中大脑区域 hMT 和 hV4 的功能和相互作用

• 批准号: RGPIN-2016-03824
• 负责人: Mullen, Kathy
• 金额: $ 2.55万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=631575
• 关键词: Functions; interactions; brain; areas; hMT+

The objective is to investigate the modularity of the human brain for the visual attributes of color, form and motion perception. Although these fundamental aspects of the visual image appear perceptually integrated, accumulated evidence suggests that they are processed separately within different, specialized areas of the brain. Two key brain areas are thought to be fundamental for the processing of these attributes: hMT+ and hV4. The human MT complex (hMT+) is traditionally considered to be part of the dorsal pathway, despite its more lateral location, and is known to be involved in motion perception, whereas hV4 is part of the ventral pathway and is thought to be involved in the processing of shape and color. Much of what we know about these two areas has been acquired from work done on non-human primates. Here we aim to test hypotheses about their functions in human vision by selectively and temporarily impairing the responses of each using a brain stimulation technique, rTMS. If stimulation of the targeted brain area results in a consistent impairment (or improvement) of a specific visual task, it is likely that the brain area is functionally involved. After localizing the relevant brain areas using fMRI, we determine the effect of brain stimulation of each area on the performance of specific visual tasks. Each task is designed to test a specialized visual function relating to motion, form or color perception. The proposed program aims to provide a comprehensive investigation of the functional roles of areas hMT+ and hV4 in vision, but also to determine the functional overlap and interactions between the areas.

我们的目标是调查的颜色，形状和运动感知的视觉属性的人脑的模块化。虽然视觉图像的这些基本方面在感知上似乎是一体的，但积累的证据表明，它们在大脑的不同专门区域内分别进行处理。两个关键的大脑区域被认为是处理这些属性的基础：hMT+和hV4。人类MT复合物（hMT+）传统上被认为是背侧通路的一部分，尽管它的位置更外侧，并且已知参与运动感知，而hV4是腹侧通路的一部分，并且被认为参与形状和颜色的处理。我们对这两个领域的了解，大部分来自于对非人类灵长类动物的研究。在这里，我们的目标是通过使用脑刺激技术rTMS选择性地和暂时地损害每个人的反应来测试关于他们在人类视觉中的功能的假设。如果刺激目标大脑区域导致特定视觉任务的持续损害（或改善），则可能涉及大脑区域的功能。在使用fMRI定位相关脑区后，我们确定了每个区域的脑刺激对特定视觉任务性能的影响。每项任务都旨在测试与运动，形状或颜色感知相关的专门视觉功能。该计划旨在全面研究hMT+和hV4区域在视觉中的功能作用，同时确定这些区域之间的功能重叠和相互作用。