Theoretical and experimental approaches in synthetic biology

合成生物学的理论和实验方法

• 批准号: RGPIN-2017-06795
• 负责人: McMillen, David
• 金额: $ 2.04万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632244
• 关键词: Theoretical; experimental; approaches; synthetic; biology

The proposal describes a program in synthetic biology, a field based on modifying living cells for human-designed purposes. Our long-term objectives are to explore methods of systematic biological system design, including mathematical and computational approaches to design new biological controllers, as well as implementing these systems experimentally in bacteria and yeast cells, to test and validate the theoretical efforts. We also aim to put our cellular systems to work, applying them to the solution of real-world problems. This research effort is interdisciplinary in nature, drawing on knowledge from physical/biological chemistry, molecular biology, biological physics, nonlinear dynamics, and engineering.

该提案描述了合成生物学的一个项目，这是一个基于人为设计目的修改活细胞的领域。我们的长期目标是探索系统生物系统设计的方法，包括设计新的生物控制器的数学和计算方法，以及在细菌和酵母细胞中实验性地实施这些系统，以测试和验证理论工作。我们还致力于将我们的蜂窝系统投入使用，将其应用于解决现实世界的问题。这项研究工作是跨学科的性质，从物理/生物化学，分子生物学，生物物理学，非线性动力学和工程知识借鉴。