Chemical biosensors for improving drug production

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Many pharmaceuticals are complex, natural compounds that can be difficult to extract from their sources or tosynthesize chemically. To overcome this, some pharmaceuticals can be produced in a host organism that iseasier to manage on a commercial scale. Hyasynth Bio has developed strains of yeast that producecannabinoids, a class of compounds with great potential as medicines and therapeutics. Early approvedcannabinoid medicines in Canada include nabiximols, for adjunctive analgesic treatment in adult patients withadvanced cancer, and nabilone, for severe nausea and vomiting associated with cancer chemotherapy. Torapidly screen yeast strains with improved cannabinoid production, a simple way of detecting and quantifyingthese compounds is required. We aim to develop a new means of detecting medicinal cannabinoids to improvetheir commercial production.