Polymer Conformation, Dynamics, Morphology

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My research is focused on developing new fundamental scientific knowledge about polymers as materials in areas where one can have an impact on modern technology or medicine. Much of our effort is devoted to the creation and study of polymer objects that form stable colloids in solution, with a uniform well-defined shape and with nanometer or micrometer dimensions. This proposal describes two broad projects, both in the area of polymer materials. One focuses on block copolymer self-assembly in solution. In collaboration with I. Manners (Bristol, UK) we have published seminal papers describing the unprecedented formation of nanofiber micelles in solution. This work has in many ways changed how scientists think about block copolymer micelle formation, particularly when the core-forming polymer is crystalline. In these studies, polyferrocenylsilane (PFS) was the core-forming block. It remains the only type of block copolymer that can form nanowires with a uniform and controllable length. Here I describe new experiments to understand mechanistically why and how such control of self assembly is possible, and how the PFS polymer molecules can fold as they add to the ends of the growing micelles to form crystals of such tiny dimensions. Because the growth of these nanofibers has key features in common with the formation of amyloid fibers associated with human diseases, but without the complications of fragmentation and aggregation, kinetic studies of PFS block copolymer micelle growth could provide important information about factors that affect nanofiber formation in solution.