Biologically Active Metal Complexes: New Designs Inspired by Mechanistic Studies

生物活性金属配合物：受机理研究启发的新设计

• 批准号: RGPIN-2017-04979
• 负责人: Walsby, Charles
• 金额: $ 2.55万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632498
• 关键词: Biologically; Active; Metal; Complexes; New

We are developing new metal complexes as probes of biological processes and for therapeutic applications. To do this, we design and synthesize molecules and study their reactions in biological environments using spectroscopic methods. These studies will produce compounds that address a primary challenge in cancer research: how to preferentially target cancer cells while leaving normal cells unaffected. This work involves three interrelated themes:

我们正在开发新的金属配合物作为生物过程的探针和治疗应用。为此，我们设计和合成分子，并使用光谱方法研究它们在生物环境中的反应。这些研究将产生解决癌症研究中主要挑战的化合物：如何优先靶向癌细胞，同时不影响正常细胞。这项工作涉及三个相互关联的主题：