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Merging transition metal-catalysis and electrochemistry for late stage functionalization of biologically active molecules

融合过渡金属催化和电化学以实现生物活性分子的后期功能化

基本信息

批准号：
2279370
负责人：
金额：
--
依托单位：
University of Manchester
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2279370
关键词：
Merging transition metal catalysis electrochemistry

项目摘要

Transition-metal catalysed C-H functionalisation reactions have proven revolutionary in recent years, with thousands of publications describing myriad protocols including cross-coupling reactions, directed and non-directed regioselective C-C bond formation (achieving alkylation, alkenylation and arylation), and selective late-stage functionalisation of complex biologically active molecules. Electrochemistry has been utilised since the 1800s, but has largely been viewed by most synthetic chemists as obscure and inaccessible until only very recently. In the past 15 years, electrochemistry has enjoyed a surge of new-found interest within the synthesis community as electrochemistry equipment has become more standardised and accessible, with chemists discovering exciting novel transformations utilising electrochemical methods. Transition-metal catalysis integrated with electrochemistry has emerged as a versatile method for C-H functionalisation, and is at the forefront of research understanding, enabling previously unknown transformations while simultaneously removing the need for stoichiometric oxidants and reductants, improving the sustainability of synthetic chemistry. This thesis details work undertaken to contribute to this exciting modern field of chemistry, by developing new methods of electrochemical transition-metal catalysed C-H functionalisation for the late-stage functionalisation of biologically active molecules

近年来，过渡金属催化的C-H功能化反应被证明是革命性的，数以千计的出版物描述了各种方案，包括交叉偶联反应、定向和非定向区域选择性C-C键的形成(实现烷基化、烯基化和芳基化)，以及复杂生物活性分子的选择性后期官能化。自19世纪以来，电化学一直被使用，但直到最近，大多数合成化学家才在很大程度上认为它晦涩难懂。在过去的15年里，随着电化学设备变得更加标准化和普及，化学家们发现了利用电化学方法进行的令人兴奋的新颖转化，电化学在合成界引起了新的兴趣。过渡金属催化与电化学相结合已成为C-H功能化的一种通用方法，并处于研究理解的前沿，使以前未知的转化成为可能，同时消除了对化学计量氧化剂和还原剂的需求，提高了合成化学的可持续性。本论文详细介绍了通过开发电化学过渡的新方法--用于生物活性分子后期官能化的金属催化的C-H官能化，为这一激动人心的现代化学领域作出贡献的工作。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Transition-Metal-Catalyzed C-H Bond Activation for the Formation of C-C Bonds in Complex Molecules.

DOI：
10.1021/acs.chemrev.2c00888
发表时间：
2023-06-28
期刊：
CHEMICAL REVIEWS
影响因子：
62.1
作者：
Docherty, Jamie H.;Lister, Thomas M.;Mcarthur, Gillian;Findlay, Michael T.;Domingo-Legarda, Pablo;Kenyon, Jacob;Choudhary, Shweta;Larrosa, Igor
通讯作者：
Larrosa, Igor

Electrochemical Ruthenium-Catalysed Directed C-H Functionalization of Arenes with Boron Reagents