Novel Detergent Systems for Membrane Protein Studies

用于膜蛋白研究的新型洗涤剂系统

• 批准号: RGPIN-2016-06360
• 负责人: Privé, Gilbert
• 金额: $ 2.19万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632525
• 关键词: Novel; Detergent; Systems; Membrane; Protein

Detergents are essential tools for the biophysical study of membrane proteins, lipids, and other hydrophobic molecules. While traditional detergents remain in wide use and are essential reagents, no single detergent has ideal properties for all applications. As a result, several new alternative solubilization systems are opening up new avenues of research. The proposed program proposes to expand on three novel technologies that are being actively developed in the Privé lab.

洗涤剂是对膜蛋白、脂类和其他疏水分子进行生物物理研究的重要工具。虽然传统洗涤剂仍在广泛使用，是必不可少的试剂，但没有一种洗涤剂具有适用于所有应用的理想性能。因此，几种新的替代增溶系统正在开辟新的研究途径。拟议的方案提议扩大私人实验室正在积极开发的三项新技术。