Structure and Function of Membrane-Associated Peptides and Proteins

膜相关肽和蛋白质的结构和功能

• 批准号: RGPIN-2017-03831
• 负责人: Straus, Suzana
• 金额: $ 3.28万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632537
• 关键词: Structure; Function; Membrane; Associated; Peptides

Every living cell is enveloped by a membrane. Therefore most biological processes either occur at or require transit through a membrane. Indeed, about a third of all proteins are membrane peptides or proteins. Despite their importance relatively little is known about the three-dimensional architecture of these proteins. Knowledge of the structure of a protein and its interaction with other partners (i.e. the membrane or other proteins) is needed to understand function, which is in turn necessary to develop novel therapeutics to combat diseases.

每个活细胞都被一层膜包裹着。因此，大多数生物过程要么发生在膜上，要么需要通过膜。事实上，大约三分之一的蛋白质是膜肽或蛋白质。尽管它们很重要，但人们对这些蛋白质的三维结构知之甚少。了解蛋白质的结构及其与其他伙伴（即膜或其他蛋白质）的相互作用是了解功能所必需的，这反过来又是开发对抗疾病的新疗法所必需的。