Fundamental Molecular Mechanisms of DNA Damage

DNA 损伤的基本分子机制

• 批准号: RGPIN-2015-06247
• 负责人: Loppnow, Glen
• 金额: $ 2.04万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632550
• 关键词: Fundamental; Molecular; Mechanisms; DNA; Damage

DNA and RNA are linear oligomers of adenosine (A), cytidine (C), and guanidine (G) nucleotides, with either uridine (U) or thymidine (T) as the fourth nucleotide in RNA and DNA, respectively. In DNA, hydrogen bonding between nucleobases on two oligomeric strands forms the iconic double-stranded B-form helix, with C pairing with G and A pairing with T. The consequent overlap and interactions between the nucleobase electronic states results in hypochromism, exciton splitting and ultrafast (sub-ps) electronic excited-state relaxation, and leads to difficulties in predicting DNA's chemical and photophysical behavior.

DNA和RNA是腺苷（A）、胞苷（C）和胍（G）核苷酸的线性寡聚体，其中尿苷（U）或胸苷（T）分别作为RNA和DNA中的第四个核苷酸。在DNA中，两条寡聚链上的核碱基之间的氢键形成了标志性的双链B型螺旋，C与G配对，A与T配对。核碱基电子态之间的重叠和相互作用导致了减色性、激子分裂和超快（亚ps）电子激发态弛豫，并导致难以预测DNA的化学和物理行为。