Exploring new experimental space with inversely-polarized phosphaalkenes and dianionic pincer ligands

用反极化磷烯和双阴离子钳配体探索新的实验空间

• 批准号: RGPIN-2017-05665
• 负责人: Lavoie, Gino
• 金额: $ 1.6万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632678
• 关键词: Exploring; new; experimental; space; inversely

Double bonds play a crucial role in synthetic chemistry. Simple olefins, such as ethylene, propylene, acrylates and other related functionalized olefins are important building blocks for the polymer industry. The reactivity of C=C double bonds can also undergo alkene metathesis (and alkyne metathesis for C≡C triple bonds) to create new value-added chemicals and materials used across the industry, from fine chemicals to perfumes, pharmaceuticals and polymers. Similarly, polar double bonds such as C=O and C=N are hydrogenated into high-value molecules, with the possibility to introduce a new chiral centre in the molecule with biological activity. Developing a solid fundamental understanding of catalysis is essential for the industry to have access to better (more stable, more active and more selective) catalysts that can mediate important transformations with a wide range of substrates.

双键在合成化学中起着关键作用。简单烯烃，如乙烯、丙烯、丙烯酸酯和其他相关的功能化烯烃是聚合物工业的重要组成部分。C=C双键的反应性也可以进行烯烃复分解（以及C≡C三键的炔复分解），以创造新的增值化学品和材料，用于整个工业，从精细化学品到香水，药品和聚合物。类似地，极性双键如C=O和C=N氢化成高价值分子，有可能在分子中引入具有生物活性的新手性中心。要想获得更好（更稳定、更活跃、更有选择性）的催化剂，从而在广泛的底物中介导重要的转化，对催化学有一个坚实的基础理解是至关重要的。